Affinity Data by PubMed id=9191958

PubMed code 9191958

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3690 (4-[(3-Bromophenyl)amino]-6-[[2-(4-imidazolyl)ethyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3684 (4-[(3-Bromophenyl)amino]-6-(methylamino)pyrimido-[...) Show SMILES CNc1ncc2ncnc(Nc3cccc(Br)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3688 (4-[(3-Bromophenyl)amino]-6-[[2-(4-morpholino)ethyl...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.810	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3685 (4-[(3-Bromophenyl)amino]-6-(dimethylamino)pyrimido...) Show SMILES CN(C)c1ncc2ncnc(Nc3cccc(Br)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.950	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3683 (4-anilinopyrimido[5,4-d]pyrimidine deriv. 5b \| 6-A...) Show SMILES Nc1ncc2ncnc(Nc3cccc(Br)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3691 (4-[(3-Bromophenyl)amino]-6-[[3-(1-imidazolyl)propy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3696 (4-[(3-Methylphenyl)amino]-6-[[2-(4-morpholino)ethy...) Show SMILES Cc1cccc(Nc2ncnc3cnc(NCCN4CCOCC4)nc23)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3689 (4-[(3-Bromophenyl)amino]-6-[[3-(4-morpholino)propy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3697 (2-N-[2-(1H-imidazol-4-yl)ethyl]-8-N-(3-methylpheny...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3686 (4-[(3-Bromophenyl)amino]-6-methoxypyrimido[5,4-d]-...) Show SMILES COc1ncc2ncnc(Nc3cccc(Br)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3695 (2-N,2-N-dimethyl-8-N-(3-methylphenyl)-[1,3]diazino...) Show SMILES CN(C)c1ncc2ncnc(Nc3cccc(C)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3694 (2-N-methyl-8-N-(3-methylphenyl)-[1,3]diazino[5,4-d...) Show SMILES CNc1ncc2ncnc(Nc3cccc(C)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3681 (2-N-methyl-8-N-phenyl-[1,3]diazino[5,4-d]pyrimidin...) Show SMILES CNc1ncc2ncnc(Nc3ccccc3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3693 (4-anilinopyrimido[5,4-d]pyrimidine deriv. 6b \| 6-A...) Show SMILES Cc1cccc(Nc2ncnc3cnc(N)nc23)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3687 (4-[(3-Bromophenyl)amino]-6-[[2-(dimethylamino)-eth...) Show SMILES CN(C)CCNc1ncc2ncnc(Nc3cccc(Br)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3682 (4-[(3-Bromophenyl)amino]-6-chloropyrimido[5,4-d]py...) Show SMILES Clc1ncc2ncnc(Nc3cccc(Br)c3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3692 (4-[(3-Methylphenyl)amino]-6-chloropyrimido[5,4-d]p...) Show SMILES Cc1cccc(Nc2ncnc3cnc(Cl)nc23)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3680 (4-anilinopyrimido[5,4-d]pyrimidine deriv. 4a \| 6-C...) Show SMILES Clc1ncc2ncnc(Nc3ccccc3)c2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.55E+3	n/a	n/a	n/a	n/a	7.4	22
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 1820-6 (1997) Article DOI: 10.1021/jm960879m BindingDB Entry DOI: 10.7270/Q2J101C8
University of Auckland					More data for this Ligand-Target Pair

* indicates data uncertainty>20%