Found 32 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061469
(1-[4-(8-CHLORO-3-METHYL-5,6-DIHYDRO-BENZO[5,6]CYCL...)Show SMILES [#6]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H26ClN3O/c1-18-14-22-3-2-21-16-23(28)4-5-24(21)26(27(22)30-17-18)20-8-12-31(13-9-20)25(32)15-19-6-10-29-11-7-19/h4-7,10-11,14,16-17H,2-3,8-9,12-13,15H2,1H3 | PDB
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061819
(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Br)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23BrClN3O/c27-21-14-20-2-1-19-15-22(28)3-4-23(19)25(26(20)30-16-21)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061811
(1-[4-(8-Chloro-3-iodo-5,6-dihydro-benzo[5,6]cycloh...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(I)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23ClIN3O/c27-21-3-4-23-19(14-21)1-2-20-15-22(28)16-30-26(20)25(23)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061818
(1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Cl)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23Cl2N3O/c27-21-3-4-23-19(14-21)1-2-20-15-22(28)16-30-26(20)25(23)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM14455
(3-bromo-4-pyridylacetyl N-oxide 1 | 4-[2-(4-{6-bro...)Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cc(Br)cnc-23)cc1 Show InChI InChI=1S/C26H23BrClN3O2/c27-21-14-20-2-1-19-15-22(28)3-4-23(19)25(26(20)29-16-21)18-7-9-30(10-8-18)24(32)13-17-5-11-31(33)12-6-17/h3-6,11-12,14-16H,1-2,7-10,13H2 | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061814
(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Br)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H23BrClN3O/c27-21-13-20-4-3-19-14-22(28)5-6-23(19)25(26(20)30-16-21)18-7-10-31(11-8-18)24(32)12-17-2-1-9-29-15-17/h1-2,5-6,9,13-16H,3-4,7-8,10-12H2 | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM14454
(1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-29-26(20)25(23)19-9-14-30(15-10-19)24(31)16-18-7-12-28-13-8-18/h1-2,5-8,11-13,17H,3-4,9-10,14-16H2 | PDB
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| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061820
(1-[4-(8-Chloro-3-methylsulfanyl-5,6-dihydro-benzo[...)Show SMILES [#6]-[#16]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H26ClN3OS/c1-33-23-16-21-3-2-20-15-22(28)4-5-24(20)26(27(21)30-17-23)19-8-12-31(13-9-19)25(32)14-18-6-10-29-11-7-18/h4-7,10-11,15-17H,2-3,8-9,12-14H2,1H3 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061825
(1-[4-(8-Chloro-3-trifluoromethyl-5,6-dihydro-benzo...)Show SMILES FC(F)(F)c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H23ClF3N3O/c28-22-3-4-23-19(15-22)1-2-20-14-21(27(29,30)31)16-33-26(20)25(23)18-7-11-34(12-8-18)24(35)13-17-5-9-32-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061489
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-7-8-23-21(16-22)6-5-20-4-2-12-29-26(20)25(23)19-9-13-30(14-10-19)24(31)15-18-3-1-11-28-17-18/h1-4,7-8,11-12,16-17H,5-6,9-10,13-15H2 | PDB
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| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061826
(1-[4-(8-Chloro-3-methoxy-5,6-dihydro-benzo[5,6]cyc...)Show SMILES [#6]-[#8]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H26ClN3O2/c1-33-23-16-21-3-2-20-15-22(28)4-5-24(20)26(27(21)30-17-23)19-8-12-31(13-9-19)25(32)14-18-6-10-29-11-7-18/h4-7,10-11,15-17H,2-3,8-9,12-14H2,1H3 | PDB
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| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061458
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C26H24ClN3O2/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-28-26(20)25(23)19-9-12-29(13-10-19)24(31)16-18-7-14-30(32)15-8-18/h1-2,5-8,11,14-15,17H,3-4,9-10,12-13,16H2 | PDB
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| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061823
(1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cycl...)Show SMILES [#6]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C27H26ClN3O/c1-18-13-22-5-4-21-15-23(28)6-7-24(21)26(27(22)30-16-18)20-8-11-31(12-9-20)25(32)14-19-3-2-10-29-17-19/h2-3,6-7,10,13,15-17H,4-5,8-9,11-12,14H2,1H3 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061824
(1-[4-(8-Chloro-3-nitro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES [#8-]-[#7+](=O)-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23ClN4O3/c27-21-3-4-23-19(14-21)1-2-20-15-22(31(33)34)16-29-26(20)25(23)18-7-11-30(12-8-18)24(32)13-17-5-9-28-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061809
(1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Cl)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H23Cl2N3O/c27-21-5-6-23-19(13-21)3-4-20-14-22(28)16-30-26(20)25(23)18-7-10-31(11-8-18)24(32)12-17-2-1-9-29-15-17/h1-2,5-6,9,13-16H,3-4,7-8,10-12H2 | PDB
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| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061812
(1-[4-(8-Chloro-3-hydroxy-5,6-dihydro-benzo[5,6]cyc...)Show SMILES [#8]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H24ClN3O2/c27-21-3-4-23-19(14-21)1-2-20-15-22(31)16-29-26(20)25(23)18-7-11-30(12-8-18)24(32)13-17-5-9-28-10-6-17/h3-6,9-10,14-16,31H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061821
(1-[4-(8-Chloro-3-fluoro-5,6-dihydro-benzo[5,6]cycl...)Show SMILES Fc1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23ClFN3O/c27-21-3-4-23-19(14-21)1-2-20-15-22(28)16-30-26(20)25(23)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061816
(1-[4-(8-Chloro-3-thiocyanato-5,6-dihydro-benzo[5,6...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(-[#16]C#N)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H23ClN4OS/c28-22-3-4-24-20(14-22)1-2-21-15-23(34-17-29)16-31-27(21)26(24)19-7-11-32(12-8-19)25(33)13-18-5-9-30-10-6-18/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061810
(1-[4-(3-Amino-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES [#7]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H25ClN4O/c27-21-3-4-23-19(14-21)1-2-20-15-22(28)16-30-26(20)25(23)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13,28H2 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061822
(1-[4-(8-Chloro-3-ethylamino-5,6-dihydro-benzo[5,6]...)Show SMILES [#6]-[#6]-[#7]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C28H29ClN4O/c1-2-31-24-17-22-4-3-21-16-23(29)5-6-25(21)27(28(22)32-18-24)20-9-13-33(14-10-20)26(34)15-19-7-11-30-12-8-19/h5-8,11-12,16-18,31H,2-4,9-10,13-15H2,1H3 | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061815
(8-Chloro-11-[1-(2-pyridin-4-yl-acetyl)-piperidin-4...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)C#N)c1 Show InChI InChI=1S/C27H23ClN4O/c28-23-3-4-24-21(15-23)1-2-22-13-19(16-29)17-31-27(22)26(24)20-7-11-32(12-8-20)25(33)14-18-5-9-30-10-6-18/h3-6,9-10,13,15,17H,1-2,7-8,11-12,14H2 | PDB
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061813
(1-[4-(8-Chloro-3-fluoro-5,6-dihydro-benzo[5,6]cycl...)Show SMILES Fc1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H23ClFN3O/c27-21-5-6-23-19(13-21)3-4-20-14-22(28)16-30-26(20)25(23)18-7-10-31(11-8-18)24(32)12-17-2-1-9-29-15-17/h1-2,5-6,9,13-16H,3-4,7-8,10-12H2 | PDB
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| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061817
(1-[4-(3-tert-Butyl-8-chloro-5,6-dihydro-benzo[5,6]...)Show SMILES [#6]C([#6])([#6])c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C30H32ClN3O/c1-30(2,3)24-17-23-5-4-22-18-25(31)6-7-26(22)28(29(23)33-19-24)21-10-14-34(15-11-21)27(35)16-20-8-12-32-13-9-20/h6-9,12-13,17-19H,4-5,10-11,14-16H2,1-3H3 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061827
(CHEMBL135374 | N-{8-Chloro-11-[1-(2-pyridin-4-yl-a...)Show SMILES [#6]S(=O)(=O)[#7]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H27ClN4O3S/c1-36(34,35)31-23-16-21-3-2-20-15-22(28)4-5-24(20)26(27(21)30-17-23)19-8-12-32(13-9-19)25(33)14-18-6-10-29-11-7-18/h4-7,10-11,15-17,31H,2-3,8-9,12-14H2,1H3 | PDB
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| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Farnesyltransferase |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061811
(1-[4-(8-Chloro-3-iodo-5,6-dihydro-benzo[5,6]cycloh...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(I)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23ClIN3O/c27-21-3-4-23-19(14-21)1-2-20-15-22(28)16-30-26(20)25(23)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | >3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061814
(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Br)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H23BrClN3O/c27-21-13-20-4-3-19-14-22(28)5-6-23(19)25(26(20)30-16-21)18-7-10-31(11-8-18)24(32)12-17-2-1-9-29-15-17/h1-2,5-6,9,13-16H,3-4,7-8,10-12H2 | PDB
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| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061819
(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Br)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23BrClN3O/c27-21-14-20-2-1-19-15-22(28)3-4-23(19)25(26(20)30-16-21)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061469
(1-[4-(8-CHLORO-3-METHYL-5,6-DIHYDRO-BENZO[5,6]CYCL...)Show SMILES [#6]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H26ClN3O/c1-18-14-22-3-2-21-16-23(28)4-5-24(21)26(27(22)30-17-18)20-8-12-31(13-9-20)25(32)15-19-6-10-29-11-7-19/h4-7,10-11,14,16-17H,2-3,8-9,12-13,15H2,1H3 | PDB
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| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061818
(1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cc(Cl)cnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H23Cl2N3O/c27-21-3-4-23-19(14-21)1-2-20-15-22(28)16-30-26(20)25(23)18-7-11-31(12-8-18)24(32)13-17-5-9-29-10-6-17/h3-6,9-10,14-16H,1-2,7-8,11-13H2 | PDB
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| n/a | n/a | >4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061823
(1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cycl...)Show SMILES [#6]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C27H26ClN3O/c1-18-13-22-5-4-21-15-23(28)6-7-24(21)26(27(22)30-16-18)20-8-11-31(12-9-20)25(32)14-19-3-2-10-29-17-19/h2-3,6-7,10,13,15-17H,4-5,8-9,11-12,14H2,1H3 | PDB
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| n/a | n/a | >4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061489
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-7-8-23-21(16-22)6-5-20-4-2-12-29-26(20)25(23)19-9-13-30(14-10-19)24(31)15-18-3-1-11-28-17-18/h1-4,7-8,11-12,16-17H,5-6,9-10,13-15H2 | PDB
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| n/a | n/a | >4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14454
(1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-29-26(20)25(23)19-9-14-30(15-10-19)24(31)16-18-7-12-28-13-8-18/h1-2,5-8,11-13,17H,3-4,9-10,14-16H2 | PDB
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| n/a | n/a | >1.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Compound was tested for the inhibition of Geranylgeranyl transferase type I |
J Med Chem 40: 4290-301 (1998)
Article DOI: 10.1021/jm970464g
BindingDB Entry DOI: 10.7270/Q2NC60B2 |
More data for this
Ligand-Target Pair | |
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