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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278461 ((2S)-2-[3-(difluoromethoxy)phenyl]-2-(dimethylamin...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 52.4 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278471 ((1S)-2-methyl-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278463 ((2S)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 56.4 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278474 ((2S)-2-(dimethylamino)-2-(3-methylphenyl)-N-[5-[[(...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 59.2 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278417 ((2S)-2-(dimethylamino)-2-(4-fluorophenyl)-N-[5-[[(...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 74.6 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278465 ((2S)-2-(azetidin-1-yl)-2-[3-(difluoromethoxy)pheny...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 77.2 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278398 ((2S)-2-(Dimethylamino)-2-phenyl-N-[5-[[(3R)-1-pyri...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 82.6 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278469 ((2S)-2-(azetidin-1-yl)-N-[5-[[(3R)-1-pyridazin-3-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 102 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278475 ((2S)-2-(Azetidin-1-yl)-2-[4-fluoro-3-(trifluoromet...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 132 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278473 ((2S)-2-(dimethylamino)-2-(4-methylphenyl)-N-[5-[[(...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 132 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278463 ((2S)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 182 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278483 ((2S)-2-(dimethylamino)-2-(o-tolyl)-N-[5-[[(3R)- | ...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 187 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278471 ((1S)-2-methyl-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 194 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278482 ((2S)-2-(dimethylamino)-2-(4-methoxyphenyl)-N- | US...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 198 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278479 ((2S)-2-(3-cyanophenyl)-2-(dimethylamino)-N-[5-[[(3...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 226 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278477 ((2S)-2-(azetidin-1-yl)-N-[5-[[(3R)-1-(6-fluoropyri...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 246 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278461 ((2S)-2-[3-(difluoromethoxy)phenyl]-2-(dimethylamin...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 261 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278463 ((2S)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 522 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278467 ((2S)-2-(azetidin-1-yl)-2-(3-methoxyphenyl)-N-[5-[[...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 944 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278475 ((2S)-2-(Azetidin-1-yl)-2-[4-fluoro-3-(trifluoromet...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 952 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278467 ((2S)-2-(azetidin-1-yl)-2-(3-methoxyphenyl)-N-[5-[[...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 981 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278465 ((2S)-2-(azetidin-1-yl)-2-[3-(difluoromethoxy)pheny...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 981 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278417 ((2S)-2-(dimethylamino)-2-(4-fluorophenyl)-N-[5-[[(...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.24E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278469 ((2S)-2-(azetidin-1-yl)-N-[5-[[(3R)-1-pyridazin-3-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278398 ((2S)-2-(Dimethylamino)-2-phenyl-N-[5-[[(3R)-1-pyri...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.72E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278480 ((2R)-2-(dimethylamino)-N-[5-[[(3R)-1-pyridazin-3-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.26E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278477 ((2S)-2-(azetidin-1-yl)-N-[5-[[(3R)-1-(6-fluoropyri...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278481 ((2R)-2-(dimethylamino)-2-(4-methoxyphenyl)-N- | US...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.75E+3 | n/a | n/a | n/a | n/a | 7.8 | 25 |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040789 (2018) BindingDB Entry DOI: 10.7270/Q2TB18X9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
