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USPatent US10072034

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-8


(Homo sapiens (Human))		BDBM277687
PNG
(5-((2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-me...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCC2CC(CO2)C(O)=O)c1
Show InChI InChI=1S/C43H49N5O11S/c1-43(2,3)27-18-36(40(55-5)37(19-27)48-60(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)59-29-13-14-44-39(23-29)45-28-20-30(54-4)22-31(21-28)57-16-15-56-25-32-17-26(24-58-32)41(49)50/h7-14,18-23,26,32,48H,15-17,24-25H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)
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n/an/a 2.80n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277693
PNG
(2-((2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCSCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O10S2/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)56-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)55-16-15-54-17-18-57-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277686
PNG
(5-((2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(m...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCc2cc(co2)C(O)=O)c1
Show InChI InChI=1S/C43H45N5O11S/c1-43(2,3)27-18-36(40(55-5)37(19-27)48-60(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)59-29-13-14-44-39(23-29)45-28-20-30(54-4)22-31(21-28)57-16-15-56-25-32-17-26(24-58-32)41(49)50/h7-14,17-24,48H,15-16,25H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)
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n/an/a 5.60n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277702
PNG
(5-((2-(3-((4-((4-(3-(5-tert-Butyl)-2-methoxy-3-(me...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCc2cc(cs2)C(O)=O)c1
Show InChI InChI=1S/C43H45N5O10S2/c1-43(2,3)27-18-36(40(55-5)37(19-27)48-60(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)58-29-13-14-44-39(23-29)45-28-20-30(54-4)22-31(21-28)57-16-15-56-24-32-17-26(25-59-32)41(49)50/h7-14,17-23,25,48H,15-16,24H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277688
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-2-methoxy-3-(...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1
Show InChI InChI=1S/C42H49N5O11S/c1-26(40(48)49)56-18-16-55-17-19-57-31-23-28(22-30(24-31)53-5)44-38-25-29(14-15-43-38)58-37-13-12-34(32-10-8-9-11-33(32)37)45-41(50)46-35-20-27(42(2,3)4)21-36(39(35)54-6)47-59(7,51)52/h8-15,20-26,47H,16-19H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)
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n/an/a 7.30n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM277676
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C40H46N6O11S/c1-40(2,3)25-19-32(37(53-5)33(20-25)46-58(6,50)51)44-39(49)43-31-11-12-34(30-10-8-7-9-29(30)31)57-35-13-14-41-38(45-35)42-26-21-27(52-4)23-28(22-26)56-18-17-54-15-16-55-24-36(47)48/h7-14,19-23,46H,15-18,24H2,1-6H3,(H,47,48)(H,41,42,45)(H2,43,44,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277682
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H46N4O10S/c1-41(2,3)26-19-34(39(51-5)36(20-26)56(6)49)45-40(48)44-33-11-12-35(32-10-8-7-9-31(32)33)55-28-13-14-42-37(24-28)43-27-21-29(50-4)23-30(22-27)54-18-17-52-15-16-53-25-38(46)47/h7-14,19-24H,15-18,25H2,1-6H3,(H,42,43)(H,46,47)(H2,44,45,48)
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n/an/a 8n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277694
PNG
(US10072034, Example 20(a) | US10072034, Example 20...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1 |w:53.57|
Show InChI InChI=1S/C42H49N5O11S/c1-26(40(48)49)56-18-16-55-17-19-57-31-23-28(22-30(24-31)53-5)44-38-25-29(14-15-43-38)58-37-13-12-34(32-10-8-9-11-33(32)37)45-41(50)46-35-20-27(42(2,3)4)21-36(39(35)54-6)47-59(7,51)52/h8-15,20-26,47H,16-19H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)
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n/an/a 10.4n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))		BDBM277677
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277685
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(N(C)S(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C42H49N5O11S/c1-42(2,3)27-20-35(40(54-6)36(21-27)47(4)59(7,51)52)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)58-29-14-15-43-38(25-29)44-28-22-30(53-5)24-31(23-28)57-19-18-55-16-17-56-26-39(48)49/h8-15,20-25H,16-19,26H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)
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n/an/a 11.7n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277683
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)S(C)(=O)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H46N4O11S/c1-41(2,3)26-19-34(39(52-5)36(20-26)57(6,49)50)45-40(48)44-33-11-12-35(32-10-8-7-9-31(32)33)56-28-13-14-42-37(24-28)43-27-21-29(51-4)23-30(22-27)55-18-17-53-15-16-54-25-38(46)47/h7-14,19-24H,15-18,25H2,1-6H3,(H,42,43)(H,46,47)(H2,44,45,48)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM277677
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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n/an/a 12n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM277676
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C40H46N6O11S/c1-40(2,3)25-19-32(37(53-5)33(20-25)46-58(6,50)51)44-39(49)43-31-11-12-34(30-10-8-7-9-29(30)31)57-35-13-14-41-38(45-35)42-26-21-27(52-4)23-28(22-26)56-18-17-54-15-16-55-24-36(47)48/h7-14,19-23,46H,15-18,24H2,1-6H3,(H,47,48)(H,41,42,45)(H2,43,44,49)
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n/an/a 14n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277696
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)(C)C(O)=O)c1
Show InChI InChI=1S/C43H51N5O11S/c1-42(2,3)27-21-35(39(55-7)36(22-27)48-60(8,52)53)47-41(51)46-34-13-14-37(33-12-10-9-11-32(33)34)59-29-15-16-44-38(26-29)45-28-23-30(54-6)25-31(24-28)57-19-17-56-18-20-58-43(4,5)40(49)50/h9-16,21-26,48H,17-20H2,1-8H3,(H,44,45)(H,49,50)(H2,46,47,51)
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n/an/a 14.4n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277701
PNG
(5-((2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(m...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCc2ccc(s2)C(O)=O)c1
Show InChI InChI=1S/C43H45N5O10S2/c1-43(2,3)26-19-35(40(55-5)36(20-26)48-60(6,52)53)47-42(51)46-34-12-13-37(33-10-8-7-9-32(33)34)58-28-15-16-44-39(24-28)45-27-21-29(54-4)23-30(22-27)57-18-17-56-25-31-11-14-38(59-31)41(49)50/h7-16,19-24,48H,17-18,25H2,1-6H3,(H,44,45)(H,49,50)(H2,46,47,51)
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n/an/a 15.3n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277690
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-3-(ethylsulf...)
Show SMILES CCS(=O)(=O)Nc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C42H49N5O11S/c1-7-59(51,52)47-36-21-27(42(2,3)4)20-35(40(36)54-6)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)58-29-14-15-43-38(25-29)44-28-22-30(53-5)24-31(23-28)57-19-18-55-16-17-56-26-39(48)49/h8-15,20-25,47H,7,16-19,26H2,1-6H3,(H,43,44)(H,48,49)(H2,45,46,50)
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n/an/a 16.3n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277689
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-3-(ethylsulfo...)
Show SMILES CCS(=O)(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C42H48N4O11S/c1-7-58(50,51)37-21-27(42(2,3)4)20-35(40(37)53-6)46-41(49)45-34-12-13-36(33-11-9-8-10-32(33)34)57-29-14-15-43-38(25-29)44-28-22-30(52-5)24-31(23-28)56-19-18-54-16-17-55-26-39(47)48/h8-15,20-25H,7,16-19,26H2,1-6H3,(H,43,44)(H,47,48)(H2,45,46,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277691
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl) isoxazol-3-y...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(on4)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C36H39N5O9/c1-36(2,3)31-21-33(41-50-31)40-35(44)39-29-9-10-30(28-8-6-5-7-27(28)29)49-24-11-12-37-32(20-24)38-23-17-25(45-4)19-26(18-23)48-16-15-46-13-14-47-22-34(42)43/h5-12,17-21H,13-16,22H2,1-4H3,(H,37,38)(H,42,43)(H2,39,40,41,44)
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n/an/a 17.2n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277677
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM277677
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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n/an/a 18n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277697
PNG
(1-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCn2cc(cn2)C(O)=O)c1
Show InChI InChI=1S/C43H47N7O10S/c1-43(2,3)28-19-36(40(57-5)37(20-28)49-61(6,54)55)48-42(53)47-35-11-12-38(34-10-8-7-9-33(34)35)60-30-13-14-44-39(24-30)46-29-21-31(56-4)23-32(22-29)59-18-17-58-16-15-50-26-27(25-45-50)41(51)52/h7-14,19-26,49H,15-18H2,1-6H3,(H,44,46)(H,51,52)(H2,47,48,53)
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n/an/a 18.1n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277680
PNG
(2-(2-(2-(3-((4-((4-(3-(5-tert-Butyl-2-methoxy-3-(m...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C42H50N6O12S2/c1-42(2,3)27-20-35(40(56-5)36(21-27)47-61(6,51)52)46-41(50)45-34-12-13-37(33-11-9-8-10-32(33)34)60-29-14-15-43-38(25-29)44-28-22-30(55-4)24-31(23-28)59-19-18-57-16-17-58-26-39(49)48-62(7,53)54/h8-15,20-25,47H,16-19,26H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)
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n/an/a 18.1n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277694
PNG
(US10072034, Example 20(a) | US10072034, Example 20...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOC(C)C(O)=O)c1 |w:53.57|
Show InChI InChI=1S/C42H49N5O11S/c1-26(40(48)49)56-18-16-55-17-19-57-31-23-28(22-30(24-31)53-5)44-38-25-29(14-15-43-38)58-37-13-12-34(32-10-8-9-11-33(32)37)45-41(50)46-35-20-27(42(2,3)4)21-36(39(35)54-6)47-59(7,51)52/h8-15,20-26,47H,16-19H2,1-7H3,(H,43,44)(H,48,49)(H2,45,46,50)
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n/an/a 19.1n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277679
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-(methoxy-d...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(C)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H46N4O9/c1-26-19-27(41(2,3)4)20-35(39(26)50-6)45-40(48)44-34-11-12-36(33-10-8-7-9-32(33)34)54-29-13-14-42-37(24-29)43-28-21-30(49-5)23-31(22-28)53-18-17-51-15-16-52-25-38(46)47/h7-14,19-24H,15-18,25H2,1-6H3,(H,42,43)(H,46,47)(H2,44,45,48)
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n/an/a 19.5n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277703
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OCCOCCOCC(O)=O)cc(OC(F)F)c4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C41H45F2N5O11S/c1-41(2,3)25-18-33(38(54-4)34(19-25)48-60(5,52)53)47-40(51)46-32-10-11-35(31-9-7-6-8-30(31)32)58-27-12-13-44-36(23-27)45-26-20-28(22-29(21-26)59-39(42)43)57-17-16-55-14-15-56-24-37(49)50/h6-13,18-23,39,48H,14-17,24H2,1-5H3,(H,44,45)(H,49,50)(H2,46,47,51)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277681
PNG
(2-(2-(2-(3-(4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-(...)
Show SMILES CNC(=O)c1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCC(O)=O)c4)c3)c3ccccc23)c1OC)C(C)(C)C
Show InChI InChI=1S/C42H47N5O10/c1-42(2,3)26-19-33(40(50)43-4)39(53-6)35(20-26)47-41(51)46-34-11-12-36(32-10-8-7-9-31(32)34)57-28-13-14-44-37(24-28)45-27-21-29(52-5)23-30(22-27)56-18-17-54-15-16-55-25-38(48)49/h7-14,19-24H,15-18,25H2,1-6H3,(H,43,50)(H,44,45)(H,48,49)(H2,46,47,51)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM277676
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C40H46N6O11S/c1-40(2,3)25-19-32(37(53-5)33(20-25)46-58(6,50)51)44-39(49)43-31-11-12-34(30-10-8-7-9-29(30)31)57-35-13-14-41-38(45-35)42-26-21-27(52-4)23-28(22-26)56-18-17-54-15-16-55-24-36(47)48/h7-14,19-23,46H,15-18,24H2,1-6H3,(H,47,48)(H,41,42,45)(H2,43,44,49)
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n/an/a 23n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly by determining the level...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM277677
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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n/an/a 23n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly by determining the level...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277676
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C40H46N6O11S/c1-40(2,3)25-19-32(37(53-5)33(20-25)46-58(6,50)51)44-39(49)43-31-11-12-34(30-10-8-7-9-29(30)31)57-35-13-14-41-38(45-35)42-26-21-27(52-4)23-28(22-26)56-18-17-54-15-16-55-24-36(47)48/h7-14,19-23,46H,15-18,24H2,1-6H3,(H,47,48)(H,41,42,45)(H2,43,44,49)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277700
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl-2-methoxy-3-(...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(=O)NS(=O)(=O)N(C)C)c1
Show InChI InChI=1S/C43H53N7O12S2/c1-43(2,3)28-21-36(41(58-7)37(22-28)48-63(8,53)54)47-42(52)46-35-13-14-38(34-12-10-9-11-33(34)35)62-30-15-16-44-39(26-30)45-29-23-31(57-6)25-32(24-29)61-20-19-59-17-18-60-27-40(51)49-64(55,56)50(4)5/h9-16,21-26,48H,17-20,27H2,1-8H3,(H,44,45)(H,49,51)(H2,46,47,52)
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n/an/a 26.3n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277684
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-3-(dimethylp...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4OC)P(C)(C)=O)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C42H49N4O10P/c1-42(2,3)27-20-35(40(52-5)37(21-27)57(6,7)50)46-41(49)45-34-12-13-36(33-11-9-8-10-32(33)34)56-29-14-15-43-38(25-29)44-28-22-30(51-4)24-31(23-28)55-19-18-53-16-17-54-26-39(47)48/h8-15,20-25H,16-19,26H2,1-7H3,(H,43,44)(H,47,48)(H2,45,46,49)
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n/an/a 26.5n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277698
PNG
(N-(3-(3-(4-((2-((3-(2-(2-(1H-Tetrazol-5-yl)methoxy...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCc2nnn[nH]2)c1
Show InChI InChI=1S/C41H47N9O9S/c1-41(2,3)26-19-34(39(55-5)35(20-26)48-60(6,52)53)45-40(51)44-33-11-12-36(32-10-8-7-9-31(32)33)59-28-13-14-42-37(24-28)43-27-21-29(54-4)23-30(22-27)58-18-17-56-15-16-57-25-38-46-49-50-47-38/h7-14,19-24,48H,15-18,25H2,1-6H3,(H,42,43)(H2,44,45,51)(H,46,47,49,50)
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n/an/a 29.2n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277692
PNG
(N-(5-(tert-Butl-2-methoxy-3-(3-(4-((2-((3-methoxy-...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCc2cc(=O)o[nH]2)c1
Show InChI InChI=1S/C43H48N6O11S/c1-43(2,3)27-19-36(41(55-5)37(20-27)49-61(6,52)53)47-42(51)46-35-11-12-38(34-10-8-7-9-33(34)35)59-30-13-14-44-39(25-30)45-28-21-31(54-4)24-32(22-28)58-18-17-56-15-16-57-26-29-23-40(50)60-48-29/h7-14,19-25,48-49H,15-18,26H2,1-6H3,(H,44,45)(H2,46,47,51)
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Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interferon gamma receptor 1


(Homo sapiens (Human))		BDBM277677
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C41H47N5O11S/c1-41(2,3)26-19-34(39(53-5)35(20-26)46-58(6,50)51)45-40(49)44-33-11-12-36(32-10-8-7-9-31(32)33)57-28-13-14-42-37(24-28)43-27-21-29(52-4)23-30(22-27)56-18-17-54-15-16-55-25-38(47)48/h7-14,19-24,46H,15-18,25H2,1-6H3,(H,42,43)(H,47,48)(H2,44,45,49)
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n/an/a 31.8n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interferon gamma receptor 1


(Homo sapiens (Human))		BDBM277676
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCC(O)=O)c1
Show InChI InChI=1S/C40H46N6O11S/c1-40(2,3)25-19-32(37(53-5)33(20-25)46-58(6,50)51)44-39(49)43-31-11-12-34(30-10-8-7-9-29(30)31)57-35-13-14-41-38(45-35)42-26-21-27(52-4)23-28(22-26)56-18-17-54-15-16-55-24-36(47)48/h7-14,19-23,46H,15-18,24H2,1-6H3,(H,47,48)(H,41,42,45)(H2,43,44,49)
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n/an/a 39.4n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277699
PNG
(2-(2-(3-((4-((4-(3-(5-(tert-Buty-2-methoxy-3-(meth...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCC(O)=O)c1
Show InChI InChI=1S/C39H43N5O10S/c1-39(2,3)24-17-32(37(51-5)33(18-24)44-55(6,48)49)43-38(47)42-31-11-12-34(30-10-8-7-9-29(30)31)54-26-13-14-40-35(22-26)41-25-19-27(50-4)21-28(20-25)53-16-15-52-23-36(45)46/h7-14,17-22,44H,15-16,23H2,1-6H3,(H,40,41)(H,45,46)(H2,42,43,47)
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n/an/a 61.9n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM277678
PNG
(2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy-3-...)
Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCOCCOCC(O)=O
Show InChI InChI=1S/C42H48N6O11S/c1-42(2,3)27-21-34(39(56-5)35(22-27)48-60(6,53)54)47-41(52)46-33-11-12-36(32-10-8-7-9-31(32)33)59-29-13-14-43-37(24-29)45-28-19-26(20-30(23-28)55-4)40(51)44-15-16-57-17-18-58-25-38(49)50/h7-14,19-24,48H,15-18,25H2,1-6H3,(H,43,45)(H,44,51)(H,49,50)(H2,46,47,52)
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n/an/a 115n/an/an/an/an/an/a



Respivert Limited; Topivert Pharma Limited

US Patent


Assay Description
PBMCs from healthy subjects are separated from whole blood using a density gradient (Lymphoprep, Axis-Shield Healthcare). Cells are added to a 96 wel...

US Patent US10072034 (2018)


BindingDB Entry DOI: 10.7270/Q2B85B49
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%