Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300907 ((2S,3R)-3-cyclopropyl-3-((RS)-2-(5′-fluoro-2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300907 ((2S,3R)-3-cyclopropyl-3-((RS)-2-(5′-fluoro-2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300910 (BDBM300911 | US10131651, Example 10) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300912 (US10131651, Example 12) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 116 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300904 ((2S,3R)-3-((R or S)-2-(1- (2,5-bis(trifluoromethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300903 ((2S, 3R)-3-((R or S)-2-(1-(2, 5-bis (trifluorometh...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300909 (3-(2-(2′,6′-dimethyl-[1,1′-biphe...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300913 (US10131651, Example 13) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 684 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300901 ((2S,3R)-3-cyclopropyl-3-((R or S)-2-(2-fluoro-4-(2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300910 (BDBM300911 | US10131651, Example 10) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300901 ((2S,3R)-3-cyclopropyl-3-((R or S)-2-(2-fluoro-4-(2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300905 ((2S,3R)-3-cyclopropyl-3-((RS)-2-(4-(5-fluoro-2-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Free fatty acid receptor 1 (Homo sapiens (Human)) | BDBM300905 ((2S,3R)-3-cyclopropyl-3-((RS)-2-(4-(5-fluoro-2-met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet... | US Patent US10131651 (2018) BindingDB Entry DOI: 10.7270/Q2XP770F | |||||||||||
More data for this Ligand-Target Pair |