Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332752 ((2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[6-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24.7 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332757 (N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25.2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332754 ((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[6-[(3R)-3-(p...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 29.8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332756 (N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30.6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332755 (2-(2-Methoxyphenyl)-N-[6-[(3R)-3-(pyridazin-3-ylam...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30.9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332753 ((2S)-2-[3-(Trifluoromethoxy)phenyl]-2-methoxy-N-[6...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 95.7 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair |