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USPatent US10233177

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369799
PNG
(US10233177, Example 51)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3NC(=O)COc23)c(c1)N1CCCC1
Show InChI InChI=1S/C20H21ClN4O3/c21-14-7-6-13(17(10-14)25-8-1-2-9-25)11-22-20(27)24-16-5-3-4-15-19(16)28-12-18(26)23-15/h3-7,10H,1-2,8-9,11-12H2,(H,23,26)(H2,22,24,27)
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n/an/a 0.100n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369798
PNG
(US10233177, Example 48)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3NC(=O)COc23)c(c1)N1CCCCC1
Show InChI InChI=1S/C22H23F3N4O3/c23-22(24,25)15-8-7-14(18(11-15)29-9-2-1-3-10-29)12-26-21(31)28-17-6-4-5-16-20(17)32-13-19(30)27-16/h4-8,11H,1-3,9-10,12-13H2,(H,27,30)(H2,26,28,31)
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n/an/a 0.130n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369788
PNG
(US10233177, Example 6)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(c1)N1CCCCC1
Show InChI InChI=1S/C21H22F3N5O2/c22-21(23,24)14-8-7-13(17(11-14)29-9-2-1-3-10-29)12-25-19(30)26-15-5-4-6-16-18(15)28-20(31)27-16/h4-8,11H,1-3,9-10,12H2,(H2,25,26,30)(H2,27,28,31)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369806
PNG
(US10233177, Example 78)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3NC(=O)COc23)c(n1)C1CCCCC1
Show InChI InChI=1S/C22H23F3N4O3/c23-22(24,25)17-10-9-14(19(29-17)13-5-2-1-3-6-13)11-26-21(31)28-16-8-4-7-15-20(16)32-12-18(30)27-15/h4,7-10,13H,1-3,5-6,11-12H2,(H,27,30)(H2,26,28,31)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369797
PNG
(US10233177, Example 47)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3NC(=O)COc23)c(c1)N1CCCC1
Show InChI InChI=1S/C21H21F3N4O3/c22-21(23,24)14-7-6-13(17(10-14)28-8-1-2-9-28)11-25-20(30)27-16-5-3-4-15-19(16)31-12-18(29)26-15/h3-7,10H,1-2,8-9,11-12H2,(H,26,29)(H2,25,27,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369805
PNG
(US10233177, Example 75)
Show SMILES CC(C)(C)c1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(c1)N1CCCC1
Show InChI InChI=1S/C23H29N5O2/c1-23(2,3)16-10-9-15(19(13-16)28-11-4-5-12-28)14-24-21(29)25-17-7-6-8-18-20(17)27-22(30)26-18/h6-10,13H,4-5,11-12,14H2,1-3H3,(H2,24,25,29)(H2,26,27,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369787
PNG
(US10233177, Example 5)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(c1)N1CCCC1
Show InChI InChI=1S/C20H20F3N5O2/c21-20(22,23)13-7-6-12(16(10-13)28-8-1-2-9-28)11-24-18(29)25-14-4-3-5-15-17(14)27-19(30)26-15/h3-7,10H,1-2,8-9,11H2,(H2,24,25,29)(H2,26,27,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369792
PNG
(US10233177, Example 13)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(c1)N1CCCCC1
Show InChI InChI=1S/C20H22ClN5O2/c21-14-8-7-13(17(11-14)26-9-2-1-3-10-26)12-22-19(27)23-15-5-4-6-16-18(15)25-20(28)24-16/h4-8,11H,1-3,9-10,12H2,(H2,22,23,27)(H2,24,25,28)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369804
PNG
(US10233177, Example 73)
Show SMILES CN(C)CCOc1cc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3/c1-28(2)8-9-31-16-10-13(20(21,22)23)7-6-12(16)11-24-18(29)25-14-4-3-5-15-17(14)27-19(30)26-15/h3-7,10H,8-9,11H2,1-2H3,(H2,24,25,29)(H2,26,27,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369794
PNG
(US10233177, Example 31)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3oc(=O)[nH]c23)c(c1)N1CCCCC1
Show InChI InChI=1S/C21H21F3N4O3/c22-21(23,24)14-8-7-13(16(11-14)28-9-2-1-3-10-28)12-25-19(29)26-15-5-4-6-17-18(15)27-20(30)31-17/h4-8,11H,1-3,9-10,12H2,(H,27,30)(H2,25,26,29)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369796
PNG
(US10233177, Example 46)
Show SMILES CN(C)c1cc(ccc1CNC(=O)Nc1cccc2NC(=O)COc12)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-26(2)15-8-12(19(20,21)22)7-6-11(15)9-23-18(28)25-14-5-3-4-13-17(14)29-10-16(27)24-13/h3-8H,9-10H2,1-2H3,(H,24,27)(H2,23,25,28)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369786
PNG
(US10233177, Example 4)
Show SMILES CN(C)c1cc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C18H18F3N5O2/c1-26(2)14-8-11(18(19,20)21)7-6-10(14)9-22-16(27)23-12-4-3-5-13-15(12)25-17(28)24-13/h3-8H,9H2,1-2H3,(H2,22,23,27)(H2,24,25,28)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369803
PNG
(US10233177, Example 72)
Show SMILES CN(C)CCOc1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C19H21F3N6O3/c1-28(2)8-9-31-16-11(6-7-14(26-16)19(20,21)22)10-23-17(29)24-12-4-3-5-13-15(12)27-18(30)25-13/h3-7H,8-10H2,1-2H3,(H2,23,24,29)(H2,25,27,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369791
PNG
(US10233177, Example 12)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(c1)N1CCCC1
Show InChI InChI=1S/C19H20ClN5O2/c20-13-7-6-12(16(10-13)25-8-1-2-9-25)11-21-18(26)22-14-4-3-5-15-17(14)24-19(27)23-15/h3-7,10H,1-2,8-9,11H2,(H2,21,22,26)(H2,23,24,27)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369809
PNG
(US10233177, Example 87)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3NC(=O)COc23)c(n1)N1CCCC1
Show InChI InChI=1S/C20H20F3N5O3/c21-20(22,23)15-7-6-12(18(27-15)28-8-1-2-9-28)10-24-19(30)26-14-5-3-4-13-17(14)31-11-16(29)25-13/h3-7H,1-2,8-11H2,(H,25,29)(H2,24,26,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369795
PNG
(US10233177, Example 39)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(n1)N1CCCC1
Show InChI InChI=1S/C19H19F3N6O2/c20-19(21,22)14-7-6-11(16(26-14)28-8-1-2-9-28)10-23-17(29)24-12-4-3-5-13-15(12)27-18(30)25-13/h3-7H,1-2,8-10H2,(H2,23,24,29)(H2,25,27,30)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369790
PNG
(US10233177, Example 11)
Show SMILES CN(C)c1cc(Cl)ccc1CNC(=O)Nc1cccc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C17H18ClN5O2/c1-23(2)14-8-11(18)7-6-10(14)9-19-16(24)20-12-4-3-5-13-15(12)22-17(25)21-13/h3-8H,9H2,1-2H3,(H2,19,20,24)(H2,21,22,25)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369802
PNG
(US10233177, Example 71)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)c(n1)N1CCCCC1
Show InChI InChI=1S/C20H21F3N6O2/c21-20(22,23)15-8-7-12(17(27-15)29-9-2-1-3-10-29)11-24-18(30)25-13-5-4-6-14-16(13)28-19(31)26-14/h4-8H,1-3,9-11H2,(H2,24,25,30)(H2,26,28,31)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369808
PNG
(US10233177, Example 86)
Show SMILES CN(C)c1nc(ccc1CNC(=O)Nc1cccc2NC(=O)COc12)C(F)(F)F
Show InChI InChI=1S/C18H18F3N5O3/c1-26(2)16-10(6-7-13(25-16)18(19,20)21)8-22-17(28)24-12-5-3-4-11-15(12)29-9-14(27)23-11/h3-7H,8-9H2,1-2H3,(H,23,27)(H2,22,24,28)
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Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369810
PNG
(US10233177, Example 89)
Show SMILES CC(C)(C)c1ccc(CNC(=O)Nc2cccc3NC(=O)COc23)cc1
Show InChI InChI=1S/C20H23N3O3/c1-20(2,3)14-9-7-13(8-10-14)11-21-19(25)23-16-6-4-5-15-18(16)26-12-17(24)22-15/h4-10H,11-12H2,1-3H3,(H,22,24)(H2,21,23,25)
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n/an/a 19.8n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369800
PNG
(US10233177, Example 67)
Show SMILES CC(C)Oc1cc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-10(2)29-15-8-12(19(20,21)22)7-6-11(15)9-23-17(27)24-13-4-3-5-14-16(13)26-18(28)25-14/h3-8,10H,9H2,1-2H3,(H2,23,24,27)(H2,25,26,28)
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UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369807
PNG
(US10233177, Example 82)
Show SMILES COc1nc(ccc1CNC(=O)Nc1cccc2NC(=O)COc12)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O4/c1-27-15-9(5-6-12(24-15)17(18,19)20)7-21-16(26)23-11-4-2-3-10-14(11)28-8-13(25)22-10/h2-6H,7-8H2,1H3,(H,22,25)(H2,21,23,26)
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n/an/a 54n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369789
PNG
(US10233177, Example 10)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)cc1
Show InChI InChI=1S/C15H13ClN4O2/c16-10-6-4-9(5-7-10)8-17-14(21)18-11-2-1-3-12-13(11)20-15(22)19-12/h1-7H,8H2,(H2,17,18,21)(H2,19,20,22)
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n/an/a 79n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369801
PNG
(US10233177, Example 69)
Show SMILES CN(C)c1nc(ccc1CNC(=O)Nc1cccc2[nH]c(=O)[nH]c12)C(F)(F)F
Show InChI InChI=1S/C17H17F3N6O2/c1-26(2)14-9(6-7-12(24-14)17(18,19)20)8-21-15(27)22-10-4-3-5-11-13(10)25-16(28)23-11/h3-7H,8H2,1-2H3,(H2,21,22,27)(H2,23,25,28)
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n/an/a 92n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM369793
PNG
(US10233177, Example 23)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]c(=O)[nH]c23)o1
Show InChI InChI=1S/C14H11F3N4O3/c15-14(16,17)10-5-4-7(24-10)6-18-12(22)19-8-2-1-3-9-11(8)21-13(23)20-9/h1-5H,6H2,(H2,18,19,22)(H2,20,21,23)
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UniChem
US Patent
n/an/a 108n/an/an/an/an/an/a



Lund University



Assay Description
Capsaicin (0.3 μM) caused an increase in [Ca2+] in the vast majority (95%) of dorsal root ganglia neurons, which were thereby identified as TRPV...

Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q20004DN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%