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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM253043 (US9493447, 2001) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM253044 (US9493447, 3001) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1) (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 545 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Bos taurus (Bovine)) | BDBM253042 (US9493447, 1001) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.74E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A2) (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform 6 of Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A1) (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1) (Homo sapiens (Human)) | BDBM253042 (US9493447, 1001) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Omeros Corporation US Patent | Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs... | US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
