ITC Summary

Reaction Details

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Cell Reactant:

Serine/threonine-protein kinase Aurora-B

Syringe Reactant:

BDBM189380

Meas. Tech.:

Enzyme Inhibition

Entry Date:

08/03/16

ΔG°:

-39±5 (kJ/mole)

pH:

8±0

Log₁₀Kb:

6.83± n/a

Temperature:

298.15±0 (K)

ΔH° :

-108±5 (kJ/mole)

ΔH_obs:

n/a

Ionic Strength:

n/a

Corrected for ΔH_ioniz:

n/a

Protons Released:

n/a

ΔC_p :

n/a

Stoich. Param.:

n/a

ΔS° :

-0.0765±0.00300 (kJ/mole-K)

Comments:

n/a

Citation

Karthigeyan, D; Surabhi, S; Mizar, P; Soumik, S; Banerjee, A; Sinha, SH; Dasgupta, D; Narayana, C; Kundu, TK A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition. Chem Biol Drug Des87:958-67 (2016) [PubMed] Article

More Info.:

Get all data from this article , ITC RUN data , Solution Info , Instrument Info

Serine/threonine-protein kinase Aurora-B

Source:

n/a

Purity:

n/a

Prep. Method:

n/a

Name:

Aurora kinase B

Synonyms:

AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B

Type:

Protein

Mol. Mass.:

39327.72

Organism:

Homo sapiens (Human)

Description:

Q96GD4

Residue:

344

Sequence:

MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA

BDBM189380

Source:

n/a

Purity:

n/a

Prep. Method:

n/a

Name

BDBM189380

Synonyms:

5-methyl-4-(2-thiazolylazo)resorcinol | PTK66

Type

Small organic molecule

Emp. Form.

C10H9N3O2S

Mol. Mass.

235.262

SMILES

Cc1cc(O)cc(O)c1\N=N\c1nccs1

Structure

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