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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Tubulin | ||
| Syringe Reactant: | BDBM50035218 | ||
| Meas. Tech.: | Enzyme Inhibition | ||
| Entry Date: | 04/06/17 | ||
| ΔG°: | -260±2 (kcal/mole) | ||
| pH: | n/a | ||
| Log10Kb: | 3.95± 3.31 | ||
| Temperature: | 303.15±0 (K) | ||
| ΔH° : | -186±0 (kcal/mole) | ||
| ΔHobs: | n/a | ||
| Ionic Strength: | n/a | ||
| n/a | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | 0.25±0 (kcal/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Zhao, W; Zhou, C; Guan, ZY; Yin, P; Chen, F; Tang, YJ Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4ß-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS Chem Biol12:746-752 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data | ||
| Tubulin | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name: | Tubulin alpha-1B chain | ||
| Synonyms: | TBA1B_BOVIN | Tubulin | ||
| Type: | Protein | ||
| Mol. Mass.: | 50133.43 | ||
| Organism: | Bos taurus (Bovine) | ||
| Description: | P81947 | ||
| Residue: | 451 | ||
| Sequence: |
| ||
| BDBM50035218 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM50035218 | ||
| Synonyms: | CHEMBL61 | PODOFILOX | Podophyllinic acid lactone | Podophyllotoxin (PTOX) | podophyllotoxin | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H22O8 | ||
| Mol. Mass. | 414.4053 | ||
| SMILES | COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12 |r| | ||
| Structure | 
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