Reaction Details | |||
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Cell Reactant: | tRNA synthetase (GlyRS) | ||
Syringe Reactant: | BDBM2 | ||
Meas. Tech.: | Isothermal Titration Calorimetry | ||
Entry Date: | 10/01/07 | ||
ΔG°: | -7.32±0.330 (kcal/mole) | ||
pH: | 7.2±n/a | ||
Log10Kb: | 5.40± 5.15 | ||
Temperature: | 298±n/a (K) | ||
ΔH° : | n/a | ||
ΔHobs : | -17.2±2.06 (kcal/mole) | ||
Ionic Strength: | n/a | ||
yes | |||
Protons Released: | n/a | ||
ΔCp : | n/a | ||
Stoich. Param.: | 1.01 | ||
ΔS° : | -0.0300±0 (kcal/mole-K) | ||
Comments: | n/a | ||
Citation | Dignam, JD; Nada, S; Chaires, JB Thermodynamic characterization of the binding of nucleotides to glycyl-tRNA synthetase. Biochemistry42:5333-40 (2003) [PubMed] Article | ||
More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
tRNA synthetase (GlyRS) | |||
Source: | Protein was expressed and purified from E. coli. | ||
Purity: | n/a | ||
Prep. Method: | Enzyme was purified by affinity chromatography. | ||
Name: | Glycine--tRNA ligase | ||
Synonyms: | GARS_BOMMO | GlyRS | Glycine--tRNA ligase | Glycyl-tRNA synthetase | tRNA synthetase (GlyRS) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76917.70 | ||
Organism: | Bombyx mori | ||
Description: | B. mori glycyltRNA synthetase was expressed in E. coli. | ||
Residue: | 680 | ||
Sequence: |
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BDBM2 | |||
Source: | Sigma-Aldrich | ||
Purity: | n/a | ||
Prep. Method: | n/a | ||
Name | BDBM2 | ||
Synonyms: | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | ATP | Brimonidine ATP | CHEMBL14249 | ||
Type | Nucleoside or nucleotide | ||
Emp. Form. | C10H16N5O13P3 | ||
Mol. Mass. | 507.181 | ||
SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| | ||
Structure |
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