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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Cell Reactant: | Heat Shock Protein 90 (Hsp90) | ||
| Syringe Reactant: | BDBM10851 | ||
| Meas. Tech.: | Isothermal Titration Calorimetry | ||
| Entry Date: | 09/29/09 | ||
| ΔG°: | -22.6± (kJ/mole) | ||
| pH: | 8±n/a | ||
| Log10Kb: | 4.08± 3.48 | ||
| Temperature: | 288.15±n/a (K) | ||
| ΔH° : | n/a | ||
| ΔHobs : | -48±0.700 (kJ/mole) | ||
| Ionic Strength: | n/a | ||
| no | |||
| Protons Released: | n/a | ||
| ΔCp : | n/a | ||
| Stoich. Param.: | n/a | ||
| ΔS° : | -0.0882± (kJ/mole-K) | ||
| Comments: | n/a | ||
| Citation |  Nilapwar, S; Williams, E; Fu, C; Prodromou, C; Pearl, LH; Williams, MA; Ladbury, JE Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. J Mol Biol392:923-36 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article , ITC RUN data , Solution Info , Data Fit Method , Instrument Info | ||
| Heat Shock Protein 90 (Hsp90) | |||
| Source: | His-tagged N-terminal domain of yeast HSP90 was expressed and purified. | ||
| Purity: | n/a | ||
| Prep. Method: | Protein was purified by using nickel affinity column, and was subsequently concentrated by an (NH4)2SO4 precipitation and purified further using gel filtration chromatography. | ||
| Name: | Heat Shock Protein 90 (Hsp90) | ||
| Synonyms: | 82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat shock protein Hsp90 heat-inducible isoform | ||
| Type: | N-terminal domain | ||
| Mol. Mass.: | 23389.88 | ||
| Organism: | Saccharomyces cerevisiae (Baker s yeast) | ||
| Description: | P02829 aa 1-207 | ||
| Residue: | 207 | ||
| Sequence: |
| ||
| BDBM10851 | |||
| Source: | n/a | ||
| Purity: | n/a | ||
| Prep. Method: | n/a | ||
| Name | BDBM10851 | ||
| Synonyms: | (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2-furo[3,2-d][1,3,2]dioxaphosphinin-2-one | (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide | ADENOSINE-3 ,5 -CYCLIC-MONOPHOSPHATE | Cyclic adenosine monophosphate | cAMP | cid_23902375 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C10H12N5O6P | ||
| Mol. Mass. | 329.2059 | ||
| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O | ||
| Structure | 
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