| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E] |
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| Ligand | BDBM507127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay |
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| IC50 | 2.00±n/a nM |
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| Citation |  Yeung, K; St. Laurent, DR; Romine, JL; Scola, PM Substituted isoquionline derivatives as immunomudulators US Patent US11046675 Publication Date 6/29/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E] |
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| Name: | Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S]/Programmed cell death 1 ligand 1 [18-239,H172E] |
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| Synonyms: | PD-1/PD-L |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Programmed cell death protein 1 [25-167,N33K], Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S] |
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| Synonyms: | Complex of Programmed cell death protein 1 [25-167,N33K] and Immunoglobulin heavy constant gamma 1 [99-330,C104S,C109S,C112S,L118I,P121S] | hPD1(25-167)-3S-IG |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42672.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15116[25-167,N33K],P01857[99-330,C104S,C109S,C112S,L118I,P121S] |
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| Residue: | 384 |
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| Sequence: | LDSPDRPWKPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPE
DRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRV
TERRAEVPTAHPSPSPRPAGQFQGSPGGGGGREPKSSDKTHTSPPSPAPELIGGSSVFLF
PPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVV
SVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQV
SLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVF
SCSVMHEALHNHYTQKSLSLSPGK
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| Component 2 |
| Name: | Programmed cell death 1 ligand 1 [18-239,H172E] |
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| Synonyms: | B7H1 | CD274 | PD1L1_HUMAN | PDCD1L1 | PDCD1LG1 | PDL1 | hPDL1(18-239)-TVMV-His |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 27269.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZQ7[18-239,H172E] |
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| Residue: | 238 |
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| Sequence: | AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQ
HSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKI
NQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDEQVLSGKTTTTNSKREEKLFNVTSTL
RINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTGSEETVRFQGHHHHHH
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| BDBM507127 |
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| n/a |
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| Name | BDBM507127 |
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| Synonyms: | US11046675, Example 1006 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H43ClN4O6 |
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| Mol. Mass. | 711.246 |
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| SMILES | Cc1c(COc2cc(OCc3cncc(c3)C#N)c3CN(CC(O)=O)CCc3c2Cl)cccc1-c1cccc(OCCCN2CC[C@@H](O)C2)c1C |r| |
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| Structure | 
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