| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM508466 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Test of TNAP Activity |
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| IC50 | 2.60±n/a nM |
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| Citation |  Miyazaki, S; Inui, M; Kurosaki, Y; Yamamoto, Y; Izumi, M; Soma, K; Pinkerton, A; Kishida, M Sulfonamide compounds US Patent US11046710 Publication Date 6/29/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM508466 |
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| n/a |
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| Name | BDBM508466 |
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| Synonyms: | US11046710, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16ClN5O4S |
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| Mol. Mass. | 421.858 |
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| SMILES | COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3c(C)nnc3-c2c1 |
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| Structure | 
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