| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
|---|
| Ligand | BDBM508514 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibitory Test of TNAP Activity |
|---|
| IC50 | 1.80±n/a nM |
|---|
| Citation |  Miyazaki, S; Inui, M; Kurosaki, Y; Yamamoto, Y; Izumi, M; Soma, K; Pinkerton, A; Kishida, M Sulfonamide compounds US Patent US11046710 Publication Date 6/29/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alkaline phosphatase, tissue-nonspecific isozyme |
|---|
| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
|---|
| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57306.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1448917 |
|---|
| Residue: | 524 |
|---|
| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
|
|
|
|---|
| BDBM508514 |
|---|
| n/a |
|---|
| Name | BDBM508514 |
|---|
| Synonyms: | 5-chloro-2-methoxy-N-[(10aS)-9-methyl-7-oxo-7,8,9,10,10a, 11-hexahydro-5H-pyrazino[2,1-c]pyrido[3,2-f][1,4]oxazepin-3-yl]benzenesulfonamide | US11046710, Example 64 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19ClN4O5S |
|---|
| Mol. Mass. | 438.885 |
|---|
| SMILES | COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3CNC(=O)CN3Cc2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
