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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM287515 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Activity Assay | ||
| IC50 | 1.40±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US11078199 Publication Date 8/3/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
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| BDBM287515 | |||
| n/a | |||
| Name | BDBM287515 | ||
| Synonyms: | (R)¿N-(1-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(ethylamino)-7-oxopyrido[2,3-d]-pyrimidin-8(7H)-yl)ethyl)piperidin-3-yl)acrylamide | US11078199, Cpd 135 | US9567334, Example 135 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H32Cl2N6O4 | ||
| Mol. Mass. | 575.487 | ||
| SMILES | CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CCC[C@H](C3)NC(=O)C=C)c2n1 |r,wD:30.33,(-7.34,-2.7,;-6,-1.93,;-6,-.39,;-4.67,.38,;-4.67,1.92,;-3.33,2.69,;-2,1.92,;-.67,2.69,;.67,1.92,;2,2.69,;2,4.23,;.67,5,;3.33,5.01,;3.33,6.55,;4.67,7.32,;4.67,4.23,;4.67,2.69,;6,1.92,;7.34,2.69,;3.33,1.92,;3.33,.38,;.67,.38,;2,-.39,;-.67,-.39,;-.67,-1.93,;.67,-2.7,;.67,-4.24,;-.67,-5.01,;-.67,-6.55,;.67,-7.32,;2,-6.55,;2,-5.01,;3.33,-7.32,;4.67,-6.55,;4.67,-5.01,;6,-7.32,;7.34,-6.55,;-2,.38,;-3.33,-.39,)| | ||
| Structure | 
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