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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM287554 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Activity Assay | ||
| IC50 | 1.40±n/a nM | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US11078199 Publication Date 8/3/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
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| BDBM287554 | |||
| n/a | |||
| Name | BDBM287554 | ||
| Synonyms: | 1-(3-(4-acryloylpiperazin-1-yl)propyl)-7-amino-3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1,6-naphthyridin-2(1H)-one | US11078199, Cpd 148 | US9567334, Example 148 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29Cl2N5O4 | ||
| Mol. Mass. | 546.446 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N)cc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(3.33,8.09,;2,7.32,;2,5.78,;3.33,5,;3.33,3.46,;4.67,2.69,;6,3.46,;2,2.69,;2,1.15,;.67,3.46,;.67,5,;-.67,5.77,;-.67,2.69,;-2,3.46,;-3.33,2.69,;-4.67,3.46,;-6,2.69,;-6,1.15,;-7.34,.38,;-4.67,.38,;-3.33,1.15,;-2,.38,;-2,-1.16,;-.67,-1.93,;-.67,-3.47,;.67,-4.24,;.67,-5.78,;2,-6.55,;3.33,-5.78,;3.33,-4.24,;2,-3.46,;4.67,-6.55,;4.67,-8.09,;6,-5.78,;7.34,-6.55,;-.67,1.15,;.67,.38,)| | ||
| Structure | 
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