| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease HTRA1 |
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| Ligand | BDBM514056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HtrA1 Enzyme Inhibition Assay |
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| IC50 | 0.400±n/a nM |
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| Citation |  Maerki, HP; Hornsperger, B; Mohr, P; Reutlinger, M; Iacone, R Difluoroketamide derivatives as HtrA1 inhibitors US Patent US11059858 Publication Date 7/13/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease HTRA1 |
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| Name: | Serine protease HTRA1 |
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| Synonyms: | HTRA | HTRA1 | HTRA1_HUMAN | PRSS11 |
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| Type: | Protein |
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| Mol. Mass.: | 51293.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92743 |
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| Residue: | 480 |
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| Sequence: | MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
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| BDBM514056 |
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| n/a |
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| Name | BDBM514056 |
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| Synonyms: | US11059858, Example 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H34ClF5N4O6 |
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| Mol. Mass. | 725.102 |
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| SMILES | COc1ccc(cc1)[C@H](NC(=O)C(Cc1cccc(Cl)c1)NC(=O)c1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)C(=O)NCC(F)(F)F |r| |
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| Structure | 
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