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TargetHigh affinity nerve growth factor receptor [G595R]
LigandBDBM515359
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 1.05±0.16 nM
Citation Dai, LDuan, XYang, YLiu, XLi, HZhao, NSun, YKong, FZhang, JZhu, YYang, LLiu, F Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof US Patent US11098060 Publication Date 8/24/2021
More Info.:Get all data from this article,  Assay Method
 
High affinity nerve growth factor receptor [G595R]
Name:High affinity nerve growth factor receptor [G595R]
Synonyms:High affinity nerve growth factor receptor (TrkA)(G595R) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA
Type:Enzyme Catalytic Domain
Mol. Mass.:87598.32
Organism:Homo sapiens (Human)
Description:P04629[G595R]
Residue:796
Sequence:
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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  Blast E-value cutoff:
BDBM515359
n/a
NameBDBM515359
Synonyms:(13E,14E,22R,24S)-12-amino-24,35-difluoro- 8-methyl-4- oxa-8-aza-1(5,3) -pyrazolo[1,5-a] pyrimidine-3(3,2)-pyridine-2(1,2)- pyrrolidylcyclononanephane-9-one | US11098060, Example 17
TypeSmall organic molecule
Emp. Form.C20H21F2N7O2
Mol. Mass.429.4232
SMILESCN1CCCOc2ncc(F)cc2[C@H]2C[C@H](F)CN2c2ccn3nc(N)c(C1=O)c3n2 |r|
Structure
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