Ki Summary

Reaction Details

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Target

High affinity nerve growth factor receptor [G595R]

Ligand

BDBM515360

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

1.24±0.15 nM

Citation

Dai, L; Duan, X; Yang, Y; Liu, X; Li, H; Zhao, N; Sun, Y; Kong, F; Zhang, J; Zhu, Y; Yang, L; Liu, F Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof US Patent US11098060 Publication Date 8/24/2021

More Info.:

Get all data from this article, Assay Method

High affinity nerve growth factor receptor [G595R]

Name:

High affinity nerve growth factor receptor [G595R]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

87598.32

Organism:

Homo sapiens (Human)

Description:

P04629[G595R]

Residue:

796

Sequence:

MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG

BDBM515360

n/a

Name

BDBM515360

Synonyms:

(13E,14E,22R,24S)-12-amino-24,35-difluoro- 6,6-dimethyl-4-oxa-8-aza-1(5,3 )-pyrazolo [1,5-a]pyrimidine-3(3,2)-pyridine-2(1,2)- pyrrolidylcyclononanephane-9-one | US11098060, Example 18

Type

Small organic molecule

Emp. Form.

C21H23F2N7O2

Mol. Mass.

443.4498

SMILES

CC1(C)CNC(=O)c2c(N)nn3ccc(nc23)N2C[C@@H](F)CC2c2cc(F)cnc2OC1 |r|

Structure