| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity nerve growth factor receptor [G595R] |
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| Ligand | BDBM515375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 1.36±0.02 nM |
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| Citation |  Dai, L; Duan, X; Yang, Y; Liu, X; Li, H; Zhao, N; Sun, Y; Kong, F; Zhang, J; Zhu, Y; Yang, L; Liu, F Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof US Patent US11098060 Publication Date 8/24/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity nerve growth factor receptor [G595R] |
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| Name: | High affinity nerve growth factor receptor [G595R] |
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| Synonyms: | High affinity nerve growth factor receptor (TrkA)(G595R) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 87598.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04629[G595R] |
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| Residue: | 796 |
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| Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHRDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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| BDBM515375 |
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| n/a |
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| Name | BDBM515375 |
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| Synonyms: | (13E,14E,22R,24S)-12-amino-24,35,6,6- tetrafluoro-4-oxa-8-aza-1(5,3)- pyrazol[1,5-a]pyrimidine-3(3,2)- pyridine-2(1,2)- pyrrolidylcyclononanephane-9-one | US11098060, Example 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17F4N7O2 |
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| Mol. Mass. | 451.3776 |
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| SMILES | Nc1nn2ccc3nc2c1C(=O)NCC(F)(F)COc1ncc(F)cc1[C@H]1C[C@H](F)CN31 |r| |
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| Structure | 
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