Reaction Details |
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Target | High affinity nerve growth factor receptor [G667C] |
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Ligand | BDBM515377 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 0.210±0.02 nM |
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Citation | Dai, L; Duan, X; Yang, Y; Liu, X; Li, H; Zhao, N; Sun, Y; Kong, F; Zhang, J; Zhu, Y; Yang, L; Liu, F Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof US Patent US11098060 Publication Date 8/24/2021 |
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More Info.: | Get all data from this article, Assay Method |
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High affinity nerve growth factor receptor [G667C] |
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Name: | High affinity nerve growth factor receptor [G667C] |
Synonyms: | High affinity nerve growth factor receptor (TrkA)(G667C) | MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 87544.27 |
Organism: | Homo sapiens (Human) |
Description: | P04629 (G667C) |
Residue: | 796 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKICDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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BDBM515377 |
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n/a |
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Name | BDBM515377 |
Synonyms: | (13E,14E,22R,24S)-12-amino- 24,35-difluoro-4-oxa-7-aza-1(5,3)- pyrazolo[1,5-a]pyrimidine- 2(1,2)-pyrrolidine-3(1,2)- benzocyclooctanephane-8-one | US11098060, Example 37 |
Type | Small organic molecule |
Emp. Form. | C19H18F2N6O2 |
Mol. Mass. | 400.382 |
SMILES | Nc1nn2ccc3nc2c1C(=O)NCCOc1ccc(F)cc1[C@H]1C[C@H](F)CN31 |r| |
Structure |
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