| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
|---|
| Ligand | BDBM515451 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Omnia Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Alexander, MD; McDonald, JJ; Ni, Y; Niu, D; Petter, RC; Qiao, L; Singh, J; Wang, T; Zhu, Z MK2 inhibitors and uses thereof US Patent US11098061 Publication Date 8/24/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-activated protein kinase 2 |
|---|
| Name: | MAP kinase-activated protein kinase 2 |
|---|
| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45579.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49137 |
|---|
| Residue: | 400 |
|---|
| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
|
|
|
|---|
| BDBM515451 |
|---|
| n/a |
|---|
| Name | BDBM515451 |
|---|
| Synonyms: | US11098061, Compound V-c-1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20N4O3 |
|---|
| Mol. Mass. | 388.4192 |
|---|
| SMILES | COc1ccc(cc1NC(=O)C=C)-c1cc(ccn1)-c1cc2C(=O)NCCn2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
