| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 2 |
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| Ligand | BDBM515461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Omnia Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Alexander, MD; McDonald, JJ; Ni, Y; Niu, D; Petter, RC; Qiao, L; Singh, J; Wang, T; Zhu, Z MK2 inhibitors and uses thereof US Patent US11098061 Publication Date 8/24/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 2 |
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| Name: | MAP kinase-activated protein kinase 2 |
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| Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45579.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49137 |
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| Residue: | 400 |
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| Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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| BDBM515461 |
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| n/a |
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| Name | BDBM515461 |
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| Synonyms: | N-(2-methyl-5-(7-oxo-7,8,9, 1-tetrahydrocyclopenta[4,5]pyrrolo[2,3-f]isoquinolin-2-yl)phenyl)acrylamide | US11098061, Compound II-e-19 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19N3O2 |
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| Mol. Mass. | 381.4266 |
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| SMILES | Cc1ccc(cc1NC(=O)C=C)-c1cc2c3[nH]c4CCC(=O)c4c3ccc2cn1 |
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| Structure | 
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