Reaction Details |
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Target | Potassium channel subfamily K member 9 |
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Ligand | BDBM515528 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition of Recombinant TASK-1 and TASK-3 In Vitro |
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IC50 | 8.60±n/a nM |
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Citation | Delbeck, M; Hahn, M; Müller, T; Lustig, K; Collins, K; Lindner, N; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders US Patent US11098063 Publication Date 8/24/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Potassium channel subfamily K member 9 |
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Name: | Potassium channel subfamily K member 9 |
Synonyms: | Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2 |
Type: | PROTEIN |
Mol. Mass.: | 42276.04 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1457494 |
Residue: | 374 |
Sequence: | MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYR
QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL
TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQ
CEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLN
LVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
CYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHS
FTDHQRLMKRRKSV
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BDBM515528 |
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n/a |
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Name | BDBM515528 |
Synonyms: | (3-Fluoro-6-methoxypyridin-2-yl)(7-{[2-(4-isopropylphenyl)imidazo[1,2-a]pyrimidin-3-yl]methyl}-3-oxa-7,9-diazabicyclo[3.3.1]non-9-yl)methanone | US11098063, Example 18 |
Type | Small organic molecule |
Emp. Form. | C29H31FN6O3 |
Mol. Mass. | 530.5932 |
SMILES | COc1ccc(F)c(n1)C(=O)N1C2COCC1CN(Cc1c(nc3ncccn13)-c1ccc(cc1)C(C)C)C2 |TLB:9:11:13.14.15:17.18.38| |
Structure |
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