| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 [166-493] |
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| Ligand | BDBM518859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzyme Inhibition Using a Biochemical Peptide Phosphorylation Assay- Caliper Assay |
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| IC50 | 410±n/a nM |
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| Citation |  Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent US11160797 Publication Date 11/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase receptor R3 [166-493] |
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| Name: | Serine/threonine-protein kinase receptor R3 [166-493] |
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| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK1)(aa 166-493) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36974.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 166-493 |
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| Residue: | 328 |
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| Sequence: | ASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGES
VAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSL
YDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCC
IADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVL
WEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLA
QMMRECWYPNPSARLTALRIKKTLQKIS
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| BDBM518859 |
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| n/a |
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| Name | BDBM518859 |
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| Synonyms: | US11160797, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N3O3 |
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| Mol. Mass. | 389.447 |
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| SMILES | COc1cc(cn(C(C)C)c1=O)-c1cncc(c1)-c1ccc2N(C)C(=O)Cc2c1 |
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| Structure | 
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