| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [353-454] |
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| Ligand | BDBM528582 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 117±n/a nM |
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| Citation |  Pham, SM; Chakravarty, S; Kankanala, J; Chen, J; Nayak, AK; Barde, A Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors US Patent US11192900 Publication Date 12/7/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [353-454] |
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| Name: | Bromodomain-containing protein 4 [353-454] |
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| Synonyms: | BRD4 | BRD4-2 | BRD4_HUMAN | Bromodomain-containing protein 4 (BD2, aa 353-454) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 11972.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885[353-454] |
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| Residue: | 102 |
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| Sequence: | QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREY
RDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF
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| BDBM528582 |
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| n/a |
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| Name | BDBM528582 |
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| Synonyms: | US11192900, Compound 2 | US11192900, Example S-9 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17F2N3O3 |
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| Mol. Mass. | 409.3855 |
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| SMILES | CNc1cc(cn(C)c1=O)-c1cc(NC(=O)C#C)ccc1Oc1ccc(F)cc1F |
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| Structure | 
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