| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [58-164] |
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| Ligand | BDBM528646 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 22.0±n/a nM |
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| Citation |  Pham, SM; Chakravarty, S; Kankanala, J; Chen, J; Nayak, AK; Barde, A Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors US Patent US11192900 Publication Date 12/7/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [58-164] |
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| Name: | Bromodomain-containing protein 4 [58-164] |
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| Synonyms: | BRD4 | BRD4-1 | BRD4_HUMAN | Bromodomain-containing protein 4 (BD1, aa 58-164) | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 12525.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885[58-164] |
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| Residue: | 104 |
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| Sequence: | NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
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| BDBM528646 |
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| n/a |
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| Name | BDBM528646 |
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| Synonyms: | US11192900, Compound 406 | US11192900, Example S-70 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F2N2O5S |
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| Mol. Mass. | 448.44 |
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| SMILES | COc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)C=C)ccc1Oc1ccc(F)cc1F |
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| Structure | 
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