Ki Summary

Reaction Details

Report a problem with these data

Target

Mitogen-activated protein kinase kinase kinase kinase 1

Ligand

BDBM529602

Substrate/Competitor

n/a

Meas. Tech.

TBHPK1 IC50 Assay

IC50

0.040±n/a nM

Citation

Balan, G; Bartlett, MJ; Chandrasekhar, J; Codelli, JA; Conway, JH; Cosman, JL; Kalla, RV; Kasun, ZA; Kim, M; Lee, SH; Lo, JR; Loyer-Drew, JA; Mitchell, SA; Perry, TD; Phillips, GB; Salvo, PJ; Swaminathan, S; Van Veldhuizen, JJ; Yeung, SC; Zablocki, J Substituted 6-azabenzimidazole compounds US Patent US11203591 Publication Date 12/21/2021

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase kinase 1

Name:

Mitogen-activated protein kinase kinase kinase kinase 1

Synonyms:

HPK1 | M4K1_HUMAN | MAP4K1

Type:

PROTEIN

Mol. Mass.:

91316.07

Organism:

Homo sapiens (Human)

Description:

ChEMBL_586597

Residue:

833

Sequence:

MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL

BDBM529602

n/a

Name

BDBM529602

Synonyms:

US11203591, Example 17

Type

Small organic molecule

Emp. Form.

C36H40FN7O2

Mol. Mass.

621.7469

SMILES

Cc1ccc(Nc2nc(cc3ncn(C4CC4)c23)-c2ccc3c(c2)N([C@H]2C[C@H](C2)N2CCC[C@@H](F)C2)C(=O)C3(C)C)cc1C(N)=O |r,wU:25.28,27.33,33.38,(-1.71,-4.45,;-.37,-3.68,;-.37,-2.14,;.96,-1.37,;2.29,-2.14,;3.63,-1.37,;3.63,.17,;2.29,.94,;2.29,2.48,;3.63,3.25,;4.96,2.48,;6.43,2.96,;7.33,1.71,;6.43,.47,;6.83,-1.02,;6.43,-2.51,;7.91,-2.11,;4.96,.94,;.96,3.25,;.96,4.79,;-.37,5.56,;-1.71,4.79,;-1.71,3.25,;-.37,2.48,;-3.17,2.78,;-3.57,1.29,;-2.8,-.04,;-4.13,-.81,;-4.9,.52,;-4.53,-2.3,;-3.42,-3.4,;-3.82,-4.91,;-5.33,-5.31,;-6.43,-4.2,;-7.91,-4.6,;-6.02,-2.7,;-4.08,4.02,;-5.62,4.02,;-3.17,5.27,;-4.26,6.36,;-2.77,6.76,;2.29,-3.68,;.96,-4.45,;.96,-5.99,;2.29,-6.76,;-.37,-6.76,)|

Structure