Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase kinase kinase kinase 1

Ligand

BDBM529865

Substrate/Competitor

n/a

Meas. Tech.

TBHPK1 IC50 Assay

IC50

0.060±n/a nM

Citation

Balan, G; Bartlett, MJ; Chandrasekhar, J; Codelli, JA; Conway, JH; Cosman, JL; Kalla, RV; Kasun, ZA; Kim, M; Lee, SH; Lo, JR; Loyer-Drew, JA; Mitchell, SA; Perry, TD; Phillips, GB; Salvo, PJ; Swaminathan, S; Van Veldhuizen, JJ; Yeung, SC; Zablocki, J Substituted 6-azabenzimidazole compounds US Patent US11203591 Publication Date 12/21/2021

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase kinase 1

Name:

Mitogen-activated protein kinase kinase kinase kinase 1

Synonyms:

HPK1 | M4K1_HUMAN | MAP4K1

Type:

PROTEIN

Mol. Mass.:

91316.07

Organism:

Homo sapiens (Human)

Description:

ChEMBL_586597

Residue:

833

Sequence:

MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL

BDBM529865

n/a

Name

BDBM529865

Synonyms:

US11203591, Example 271

Type

Small organic molecule

Emp. Form.

C38H45F3N8O2

Mol. Mass.

702.8115

SMILES

CCNC(=O)c1cc(Nc2nc(cc3ncn(C(C)C)c23)-c2cc3N(C4CC(C)(C4)N4CCCCC4)C(=O)C(C)(C)c3nc2F)c(F)c(F)c1C |(1.2,-10.25,;2.53,-9.48,;2.53,-7.94,;3.86,-7.17,;5.2,-7.94,;3.86,-5.63,;5.2,-4.86,;5.2,-3.32,;6.53,-2.55,;6.53,-1.01,;5.2,-.24,;5.2,1.3,;6.53,2.07,;7.87,1.3,;9.33,1.78,;10.23,.53,;9.33,-.71,;9.81,-2.18,;11.31,-2.5,;8.78,-3.32,;7.87,-.24,;3.86,2.07,;2.53,1.3,;1.2,2.07,;-.27,1.6,;-.74,.13,;-.04,-1.24,;-1.42,-1.94,;-1.06,-3.44,;-2.12,-.57,;-2.59,-2.94,;-2.31,-4.45,;-3.48,-5.45,;-4.93,-4.94,;-5.21,-3.43,;-4.04,-2.43,;-1.17,2.84,;-2.71,2.84,;-.27,4.09,;.04,5.6,;-1.4,5.13,;1.2,3.61,;2.53,4.38,;3.86,3.61,;5.2,4.38,;3.86,-2.55,;3.86,-1.01,;2.53,-3.32,;1.2,-2.55,;2.53,-4.86,;1.2,-5.63,)|

Structure