| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK3 [811-1124] |
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| Ligand | BDBM147644 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Activity Assay |
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| IC50 | 10000±n/a nM |
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| Citation |  Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Aza-indazole compounds for use in tendon and/or ligament injuries US Patent US11203595 Publication Date 12/21/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK3 [811-1124] |
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| Name: | Tyrosine-protein kinase JAK3 [811-1124] |
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| Synonyms: | JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124) |
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| Type: | Protein |
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| Mol. Mass.: | 35601.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P52333[811-1124] |
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| Residue: | 314 |
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| Sequence: | CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQR
EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYS
SQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP
IFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRL
LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAF
TAHPEGKHHSLSFS
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| BDBM147644 |
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| n/a |
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| Name | BDBM147644 |
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| Synonyms: | US10766894, Compound TABLE 1.6 | US11203595, TABLE 1.6 | US8962608, 25-24 | US8962608, 25-5 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F3N5O2 |
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| Mol. Mass. | 393.363 |
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| SMILES | NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](O)C[C@@H]1C#N |r| |
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| Structure | 
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