| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [866-1154] |
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| Ligand | BDBM103727 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Activity Assay |
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| IC50 | 50.0±n/a nM |
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| Citation |  Bursulaya, B; Fisch, A; Lajiness, JP; Machauer, R; Malekar, S; Petrassi, HM; Ramazani, F; Remond, A; Ullrich, T; Usselmann, P; Vangrevelinghe, E Aza-indazole compounds for use in tendon and/or ligament injuries US Patent US11203595 Publication Date 12/21/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [866-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [866-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
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| Type: | Protein |
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| Mol. Mass.: | 33185.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[866-1154] |
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| Residue: | 289 |
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| Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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| BDBM103727 |
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| n/a |
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| Name | BDBM103727 |
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| Synonyms: | US10112907, Example 00033 | US10206907, Compound 200 | US10708263, Compound 1 | US10766894, Compound TABLE 1.18 | US10919890, Compound 1 | US10961228, Example Filgotinib | US11000528, Cpd # 1 | US11203595, TABLE 1.18 | US11279699, Compound Filgotinib | US8563545, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N5O3S |
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| Mol. Mass. | 425.504 |
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| SMILES | O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1 |
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| Structure | 
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