| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent phosphate transport protein 2A |
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| Ligand | BDBM531521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| IC50 | 3.00±n/a nM |
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| Citation |  Giese, A; Klar, J; Ehrmann, AH; Willwacher, J; Engel, D; Dieskau, AP; Kahnert, A; Gromov, A; Schmeck, C; Lindner, N; Müller, T; Andreevski, AL; Dreher, J; Collins, K Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof US Patent US11208400 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent phosphate transport protein 2A |
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| Name: | Sodium-dependent phosphate transport protein 2A |
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| Synonyms: | NPT2 | NPT2A_HUMAN | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | NaPi-3 | SLC17A2 | SLC34A1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68955.19 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_116742 |
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| Residue: | 639 |
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| Sequence: | MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEH
TCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDM
LSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLE
VSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAA
TGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHS
LIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLV
LLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSS
VFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFF
NISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQV
MVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCC
ARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
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| BDBM531521 |
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| n/a |
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| Name | BDBM531521 |
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| Synonyms: | 4-[5-({6-[4-chloro-5-(difluoromethyl)-3-methyl-1H-pyrazol-1-yl]pyrimidin-4-yl}amino)-1-(cyclopropylmethyl)-4-methyl-1H-pyrazol-3-yl]benzonitrile | US11208400, Example 154 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21ClF2N8 |
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| Mol. Mass. | 494.927 |
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| SMILES | Cc1nn(c(C(F)F)c1Cl)-c1cc(Nc2c(C)c(nn2CC2CC2)-c2ccc(cc2)C#N)ncn1 |
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| Structure | 
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