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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Coagulation factor XI | ||
| Ligand | BDBM304183 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Factor XIa Assay | ||
| IC50 | 1.30±n/a nM | ||
| Citation |  Shen, D; Kuang, R; Kumar, P; Duffy, JL; Zhu, C; Ali, A; Yang, M; Debenham, JS Factor XIa inhibitors US Patent US10143681 Publication Date 12/4/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Coagulation factor XI | |||
| Name: | Coagulation factor XI | ||
| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 70130.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P03951 | ||
| Residue: | 625 | ||
| Sequence: |
| ||
| BDBM304183 | |||
| n/a | |||
| Name | BDBM304183 | ||
| Synonyms: | 2-(1-((4- carboxyphenyl)amino)-3-(3- methylcyclobutyl)-1- oxopropan-2-yl)-5-(3- chloro-2-fluoro-6- (trifluoromethyl)phenyl) pyridine 1-oxide | US10143681, Example 74 | US10143681, Example 75 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H23ClF4N2O4 | ||
| Mol. Mass. | 550.929 | ||
| SMILES | CC1CC(CC(C(=O)Nc2ccc(cc2)C(O)=O)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)(F)F)C1 |$;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$,(-5.22,5.55,;-3.89,4.78,;-2.4,5.18,;-2,3.69,;-.67,2.92,;-.67,1.38,;.67,.61,;.67,-.93,;2,1.38,;3.33,.61,;3.33,-.93,;4.67,-1.7,;6,-.93,;6,.61,;4.67,1.38,;7.34,-1.7,;7.34,-3.24,;8.67,-.93,;-2,.61,;-3.33,1.38,;-4.67,.61,;-4.67,-.93,;-3.33,-1.7,;-2,-.93,;-.67,-1.7,;-6,-1.7,;-6,-3.24,;-4.67,-4.01,;-7.34,-4.01,;-7.34,-5.55,;-8.67,-3.24,;-8.67,-1.7,;-7.34,-.93,;-7.34,.61,;-7.34,2.15,;-8.67,1.38,;-6,1.38,;-3.49,3.29,)| | ||
| Structure | 
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