| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM465376 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| IC50 | 2750±n/a nM |
|---|
| Citation |  Fuller, NO; Lowe, III, JA Bicyclic inhibitors of histone deacetylase US Patent US11225479 Publication Date 1/18/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM465376 |
|---|
| n/a |
|---|
| Name | BDBM465376 |
|---|
| Synonyms: | US10793567, Compound 11 | US11225479, Compound 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17N7O |
|---|
| Mol. Mass. | 335.3632 |
|---|
| SMILES | Cn1cc2CN(Cc2n1)C(=O)Nc1nc(ccc1N)-c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
