| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 14 |
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| Ligand | BDBM536563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | USP14 Inhibition Assay |
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| IC50 | 550±n/a nM |
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| Citation |  Cullen, M; Hauck, S; Geng, B; Foley, M; Bastos, CM; Munoz, B; Haeberlein, M; Tait, B Proteasome activity enhancing compounds US Patent US11242361 Publication Date 2/8/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 14 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 14 |
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| Synonyms: | Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56058.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103728 |
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| Residue: | 494 |
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| Sequence: | MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV
QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH
MAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKK
SLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCT
PELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDL
QAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLY
GPRRVEIMEEESEQ
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| BDBM536563 |
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| n/a |
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| Name | BDBM536563 |
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| Synonyms: | 4-(2,6-Dimethyl-3-(2-(piperidin-1-yl)acetyl)-1H-indol-1-yl)benzonitrile | US11242361, Compound 169 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N3O |
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| Mol. Mass. | 371.4748 |
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| SMILES | Cc1c(C(=O)CN2CCCCC2)c2ccc(C)cc2n1-c1ccc(cc1)C#N |
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| Structure | 
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