| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM543982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro hGGPPS Inhibition Assay |
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| IC50 | 2550±n/a nM |
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| Citation |  Tsantrizos, YS; Sebag, M Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof US Patent US11279719 Publication Date 3/22/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM543982 |
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| n/a |
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| Name | BDBM543982 |
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| Synonyms: | US11279719, Example I-14 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N5O7P2S |
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| Mol. Mass. | 521.38 |
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| SMILES | OP(O)(=O)C(Nc1nc(nc2sccc12)-c1cccc(NC(=O)c2ccccn2)c1)P(O)(O)=O |
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| Structure | 
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