Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM543983 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro hGGPPS Inhibition Assay |
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IC50 | 2550±n/a nM |
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Citation | Tsantrizos, YS; Sebag, M Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof US Patent US11279719 Publication Date 3/22/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM543983 |
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n/a |
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Name | BDBM543983 |
Synonyms: | US11279719, Example I-15 |
Type | Small organic molecule |
Emp. Form. | C17H18N4O7P2S |
Mol. Mass. | 484.36 |
SMILES | OP(O)(=O)C(Nc1nc(nc2sccc12)-c1cccc(NC(=O)C2CC2)c1)P(O)(O)=O |
Structure |
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