| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM546639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RORgamma Assay |
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| IC50 | 60.0±n/a nM |
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| Citation |  Jiang, X; Bender, CF; Visnick, M; Hotema, MR; Sheldon, ZS; Lee, C; Caprathe, BW; Bolton, G; Kornberg, B Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses US Patent US11292781 Publication Date 4/5/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM546639 |
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| n/a |
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| Name | BDBM546639 |
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| Synonyms: | US11292781, Compound T122 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H26F2N4O |
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| Mol. Mass. | 520.5718 |
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| SMILES | CC1(C)[C@H]2CCc3c(nc(nc3[C@]2(C)C=C(C#N)C1=O)-c1cc(CF)nc2ccccc12)-c1ccccc1F |r,t:16| |
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| Structure | 
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