| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase basic protein 2 |
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| Ligand | BDBM552297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EN PA FRET Inhibition Assay |
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| IC50 | 2.00±n/a nM |
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| Citation |  Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent US11312727 Publication Date 4/26/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase basic protein 2 |
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| Name: | Polymerase basic protein 2 |
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| Synonyms: | B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3 |
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| Type: | Protein |
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| Mol. Mass.: | 85824.43 |
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| Organism: | Influenza A virus (strain A/WS/1933 H1N1) |
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| Description: | B4URF7 |
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| Residue: | 759 |
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| Sequence: | MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFE
KVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRI
SKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNK
TTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
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| BDBM552297 |
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| n/a |
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| Name | BDBM552297 |
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| Synonyms: | (18*R,*Z)-4-fluoro-12-hydroxy-18-(2-(methylthio)phenyl)-6,9-dihydro-18H-10,17-methanobenzo[b]pyrido[1,2-f][1]oxa[5,6,9]triazacyclotridecine-11,13-dione (Compound 119A) | US11312727, Compound 119B |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22FN3O4S |
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| Mol. Mass. | 479.523 |
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| SMILES | CSc1ccccc1[C@H]1N2CN(C\C=C/COc3c(F)cccc13)C(=O)c1c(O)c(=O)ccn21 |r,c:14| |
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| Structure | 
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