| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase basic protein 2 |
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| Ligand | BDBM552421 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Influenza Antiviral Assay |
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| EC50 | 0.600±n/a nM |
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| Citation |  Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent US11312727 Publication Date 4/26/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase basic protein 2 |
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| Name: | Polymerase basic protein 2 |
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| Synonyms: | B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3 |
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| Type: | Protein |
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| Mol. Mass.: | 85824.43 |
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| Organism: | Influenza A virus (strain A/WS/1933 H1N1) |
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| Description: | B4URF7 |
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| Residue: | 759 |
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| Sequence: | MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFE
KVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRI
SKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNK
TTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
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| BDBM552421 |
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| n/a |
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| Name | BDBM552421 |
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| Synonyms: | (21a′*R,*E)-24′,25′-difluoro-16′-hydroxy-6′,21a′-dihydro-10′H-spiro[cyclobutane-1,13′-[7,8](epiprop[1]en[1]yl[3]ylidene)[14,21]methanopyrido[1,2-f]pyrido[2′,3′:6,7]thiepino[4,5-c][1]oxa[5,6,9]triazacyclotridecine]-15′,17′-dione (Compound 168A) | US11312727, Compound 168B |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22F2N4O4S |
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| Mol. Mass. | 536.55 |
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| SMILES | Oc1c2C(=O)N3CN([C@@H]4c5ncccc5SCc5c(F)c(F)cc(OC\C=C\C33CCC3)c45)n2ccc1=O |r,t:27| |
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| Structure | 
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