| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polymerase basic protein 2 |
|---|
| Ligand | BDBM552443 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | EN PA FRET Inhibition Assay |
|---|
| IC50 | 6.50±n/a nM |
|---|
| Citation |  Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent US11312727 Publication Date 4/26/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polymerase basic protein 2 |
|---|
| Name: | Polymerase basic protein 2 |
|---|
| Synonyms: | B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 85824.43 |
|---|
| Organism: | Influenza A virus (strain A/WS/1933 H1N1) |
|---|
| Description: | B4URF7 |
|---|
| Residue: | 759 |
|---|
| Sequence: | MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFE
KVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRI
SKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNK
TTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
|
|
|
|---|
| BDBM552443 |
|---|
| n/a |
|---|
| Name | BDBM552443 |
|---|
| Synonyms: | US11312727, Compound 176BA |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H23F2N3O5S |
|---|
| Mol. Mass. | 551.561 |
|---|
| SMILES | Oc1c2C(=O)N3CN([C@@H]4c5ccccc5SCc5c(F)c(F)cc(OC\C=C\[C@@]33CCOC3)c45)n2ccc1=O |r,t:27| |
|---|
| Structure | 
|
|---|
Search and Browse
