| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 |
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| Ligand | BDBM553942 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Anisotropy Binding Assay |
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| IC50 | 9300±n/a nM |
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| Citation |  Johannes, JW; Hande, SM; Degorce, SL; Packer, MJ Chemical compounds US Patent US11325906 Publication Date 5/10/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60091.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109545 |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM553942 |
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| n/a |
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| Name | BDBM553942 |
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| Synonyms: | US11325906, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25ClN6O2 |
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| Mol. Mass. | 440.926 |
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| SMILES | CCc1cc2ncc(CN3CCN(CC3)c3ccc(nc3Cl)C(=O)NC)cc2[nH]c1=O |
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| Structure | 
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