| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 |
|---|
| Ligand | BDBM553959 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Anisotropy Binding Assay |
|---|
| IC50 | 2600±n/a nM |
|---|
| Citation |  Johannes, JW; Hande, SM; Degorce, SL; Packer, MJ Chemical compounds US Patent US11325906 Publication Date 5/10/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein mono-ADP-ribosyltransferase PARP3 |
|---|
| Name: | Protein mono-ADP-ribosyltransferase PARP3 |
|---|
| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60091.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109545 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
|
|
|
|---|
| BDBM553959 |
|---|
| n/a |
|---|
| Name | BDBM553959 |
|---|
| Synonyms: | US11325906, Example 22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24F2N6O2 |
|---|
| Mol. Mass. | 442.4618 |
|---|
| SMILES | CNC(=O)c1ccc(cn1)N1CCN(Cc2ccc3nc(c(=O)[nH]c3c2)C(C)(F)F)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
