| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM435719 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Hotspot Assay |
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| IC50 | 459±n/a nM |
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| Citation |  Mahmoud, GE; Choi, HS; Yoo, KH; Han, DK; Oh, CH; Mohammed, A; Mohammed, IE; Ammar, UM Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same US Patent US11332479 Publication Date 5/17/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM435719 |
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| n/a |
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| Name | BDBM435719 |
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| Synonyms: | US10570155, Compound 2III | US11332479, Compound 2III |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22N6O3S2 |
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| Mol. Mass. | 506.6 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)NCCNc1nccc(n1)-c1c(nc2sccn12)-c1ccccc1 |
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| Structure | 
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