Reaction Details |
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Target | Histone deacetylase 6 |
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Ligand | BDBM556400 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Histone Deacetylase Assay |
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IC50 | 19.0±n/a nM |
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Citation | Rajagopal, S; Hallur, MS; Dewang, P; Murugan, K; Kumar C. H., DP; Iyer, P; Mulakala, C; Sivanandhan, D; Nair, S; Zainuddin, M; Tantry, SJ; Gajendran, C; Rajagopal, S Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors US Patent US11352322 Publication Date 6/7/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 6 |
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Name: | Histone deacetylase 6 |
Synonyms: | Cereblon/Histone deacetylase 6 | HD6 | HDAC6 | HDAC6_HUMAN | Histone deacetylase 6 (HDAC6) | Human HDAC6 | KIAA0901 | ORF Names:JM21 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 131381.51 |
Organism: | Homo sapiens (Human) |
Description: | Q9UBN7 |
Residue: | 1215 |
Sequence: | MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLG
QAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLI
QEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNS
YSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQ
KHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQG
QGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATP
AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSA
QASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSR
TGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCH
SAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLN
GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMF
EDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWH
RLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEG
GYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVE
DREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSET
AVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGA
ILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQ
TPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEA
AGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQ
ENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKN
IAHQNKFGEDMPHPH
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BDBM556400 |
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n/a |
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Name | BDBM556400 |
Synonyms: | 4-(3-(4-(((2-(4′-chloro-[1,1′-biphenyl]-4-yl)cyclopropyl)amino)methyl)piperidin-1-yl)propyl)-N-hydroxybenzamide TFA Salt | US11352322, Compound 56 |
Type | Small organic molecule |
Emp. Form. | C31H36ClN3O2 |
Mol. Mass. | 518.089 |
SMILES | ONC(=O)c1ccc(CCCN2CCC(CNC3CC3c3ccc(cc3)-c3ccc(Cl)cc3)CC2)cc1 |
Structure |
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