| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arginase-1 |
|---|
| Ligand | BDBM568453 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Activity of Examples 1 to 30 |
|---|
| IC50 | 4550±n/a nM |
|---|
| Citation |  Mlynarski, SN; Grebe, T; Kawatkar, S; Finlay, MR; Simpson, I; Wang, J; Cook, S; Wu, D Arginase inhibitors and methods of use thereof US Patent US11420984 Publication Date 8/23/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arginase-1 |
|---|
| Name: | Arginase-1 |
|---|
| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 34737.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_978893 |
|---|
| Residue: | 322 |
|---|
| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
|
|
|
|---|
| BDBM568453 |
|---|
| n/a |
|---|
| Name | BDBM568453 |
|---|
| Synonyms: | US11420984, Example 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H18BNO5 |
|---|
| Mol. Mass. | 231.054 |
|---|
| SMILES | OB(O)CCCC[C@@]1(C[C@@H](O)CN1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
