| Reaction Details |
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 | Report a problem with these data |
| Target | Arginase-1 |
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| Ligand | BDBM568469 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Activity of Examples 1 to 30 |
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| IC50 | 220±n/a nM |
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| Citation |  Mlynarski, SN; Grebe, T; Kawatkar, S; Finlay, MR; Simpson, I; Wang, J; Cook, S; Wu, D Arginase inhibitors and methods of use thereof US Patent US11420984 Publication Date 8/23/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Arginase-1 |
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| Name: | Arginase-1 |
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| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34737.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_978893 |
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| Residue: | 322 |
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| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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| BDBM568469 |
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| n/a |
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| Name | BDBM568469 |
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| Synonyms: | US11420984, Example 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H26BN3O4 |
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| Mol. Mass. | 311.185 |
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| SMILES | CC(C)[C@H](N)C(=O)N[C@H]1CN[C@]2(C1)CCCCB(O)OC2=O |r,$;;;;;;;N;;;;;;;;;;;;;;$| |
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| Structure | 
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