Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM574838 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ZH2 biochemical assay (IC50) | ||
| IC50 | 0.5±n/a nM | ||
| Citation |  Brenneman, JB; Côté, A; Gehling, VS; Khanna, A; Levell, JR; Moine, L Modulators of methyl modifying enzymes, compositions and uses thereof US Patent US11459315 Publication Date 10/4/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
| ||
| BDBM574838 | |||
| n/a | |||
| Name | BDBM574838 | ||
| Synonyms: | US11459315, Example 4 (isomer 1) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H40N4O3S | ||
| Mol. Mass. | 536.729 | ||
| SMILES | COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12 |r,wD:9.13,12.14,(10.41,-4.86,;8.88,-5.38,;7.95,-4.04,;6.45,-3.78,;6.68,-2.36,;8.21,-2.54,;5.71,-1.01,;4.21,-1.16,;3.32,.03,;3.92,1.45,;5.45,1.64,;6.34,.4,;2.95,2.72,;3.62,4.1,;1.45,2.49,;.37,3.69,;.74,5.26,;-.97,3.13,;-2.39,3.84,;-2.39,5.38,;-3.7,3.02,;-5.08,3.84,;-6.38,3.09,;-6.42,1.52,;-5.07,.7,;-5.07,-.84,;-7.65,.78,;-9.1,1.52,;-10.41,.78,;-9.11,3.02,;-7.8,3.84,;-7.8,5.38,;-.86,1.49,;-1.83,.44,;-1.38,-1.09,;.15,-1.35,;1.12,-.3,;.63,1.23,)| | ||
| Structure | 
| ||