Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM574841 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ZH2 biochemical assay (IC50) | ||
| IC50 | 0.5±n/a nM | ||
| Citation |  Brenneman, JB; Côté, A; Gehling, VS; Khanna, A; Levell, JR; Moine, L Modulators of methyl modifying enzymes, compositions and uses thereof US Patent US11459315 Publication Date 10/4/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
| ||
| BDBM574841 | |||
| n/a | |||
| Name | BDBM574841 | ||
| Synonyms: | US11459315, Example 5 (isomer 2) | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H38N4O4S | ||
| Mol. Mass. | 526.691 | ||
| SMILES | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2OCC(CO2)NC(C)(C)C)c2ccccc12 |r,wU:20.26,wD:18.19,(-4.64,-1.85,;-4.64,-.31,;-6,.52,;-7.21,-.2,;-8.68,.52,;-9.96,-.2,;-8.69,2.02,;-7.36,2.8,;-7.36,4.34,;-5.97,2.12,;-4.68,2.84,;-3.36,2.02,;-2.04,2.8,;-2.04,4.34,;-.65,2.12,;.67,2.69,;1.03,4.27,;1.75,1.52,;3.28,1.73,;3.89,3.12,;4.18,.48,;5.71,.59,;6.61,-.59,;5.96,-2.02,;4.46,-2.16,;3.57,-.98,;6.89,-3.34,;8.43,-3.13,;9.43,-4.34,;8.89,-1.63,;9.96,-2.84,;.96,.19,;1.46,-1.27,;.46,-2.38,;-1.04,-2.06,;-1.5,-.63,;-.5,.52,)| | ||
| Structure | 
| ||